A structure in all living cells that carries the genes that determine heredity. In all cells except bacterial cells, the chromosomes are thread-like strands of DNA and protein that are contained in the nucleus. They occur in pairs in all of the cells of eukaryotes except the reproductive cells...
the alleles are different and the homologous chromosomes are described asheterozygous. On the contrary, when the alleles are the same (e.g. both alleles for the same gene code for the blue-eye trait) then, they are said to behomozygous. The significance of alleles was demonstrated by Gregor...
In general, heterozygous animal cells express both alleles at a particular locus. The only exceptions are cells of XX genotype after inactivation of one X chromosome1, and immunoglobulin-producing cells; in each case only one of the two alleles is expressed in differentiated cells and their ...
In general, heterozygous animal cells express both alleles at a particular locus. The only exceptions are cells of XX genotype after inactivation of one X chromosome1, and immunoglobulin-producing cells; in each case only one of the two alleles is expressed in differentiated cells and their progen...
We determined the translocation region of chromosomes in patient with t(3;5)(q24;q13) balanced chromosomal translocation by shallow whole-genome sequencing, which is helpful to pinpoint the chromosomal break point. We showed that SCS can physically separate and independently sequence three copies of...
In mutants heterozygous for chromosomal rearrangements, homologs will undergo considerable contortions in order to maintain synapsis, which is often interrupted only in the im- mediate area of the breakpoint. It is not known when during development homologs of polytene chromosomes become y The ...
We observed the same frequency and types of variant alleles in FSHD patients and controls, but we found marked differences between the repeat arrays of the 4q and 10q chromosomes. In particular we detected 10q alleles completely replaced by the 4q subtelomeric region, consisting in the whole ...
Twitter Google Share on Facebook homologous chromosomes (redirected fromhomologous chromosome) Also found in:Dictionary,Thesaurus,Medical,Wikipedia. [hə¦mäl·ə·gəs′krō·mə‚sōmz] (genetics) Apairofchromosomes,oneinheritedfromeachparent,thathavecorrespondinggenesequencesandthatpairduring...
Cases are represented in rows and chromosomes in columns along the x-axis. Immunohistochemical features, PALB2 germline mutation type, presence of a somatic PALB2 mutation or loss of heterozygosity (LOH) of the PALB2 wild-type allele, large-scale state transition (LST) score, mutational ...
(ACMG Class 4)16. This variant was accompanied by somatic deletion of theCHEK2wild-type allele and co-occurred with biallelic somaticPTENalterations (heterozygous p.G251V mutation and deletion of the wild-type allele). Three patients had germline variants of uncertain significance (ACMG Class 3)...