Fig. 1: Nicotine enhanced NAMPT activity in aged mice. aSchematic diagram of the changes in NAMPT activity and nicotine enhancing NAMPT activity in various tissues (the bars represent the mean value of NAMPT activity). Statistical diagram of NAMPT activity change of different tissues:bCortex,cHipp...
5E), thereby pointing toward a CgSnf3-indepdendent role of CgYapsins in regulating CgRGT1 gene expression. Of note, the Cgsnf3Δyps1-11Δ mutant exhibited low-glucose–responsive transcriptional downregulation of the CgHXT1 gene, similar to the Cgsnf3Δ mutant (Fig. 5E). Furthermore, like...
Remarkably, both our Golgi proteomics as well as our glycomic analysis converge on the glycosyltransferase B3GNT6. A total of 10 glycosyltransferases were found to be decreased in common between TVP23B and YIPF6-deficient Golgi, speaking to the broad affect TVP23B has in regulating intestinal glyc...
Central stress systems. The concept diagram on the left (reproduced with permission of the American College of Physicians) shows the Chrousos and Gold model of “the central stress system.” The concept diagram on the right relates the central stress system to the central autonomic network.CINGci...
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing facto
a Venn diagram of laser capture microdissection RNA-seq analysis showing DEGs for NP vs. 8 dpc (left) and NP vs. 16 dpc (right) in each zone. b Heatmap of DEGs for NP vs. 8 dpc in each zone. The mean of three independent experiments is shown. c GO analysis of upregulated genes...
The gut microbiota of the neonate has profound impacts on host health by regulating intestinal nutrient metabolism, maturation of the immune system, and maintenance of the intestinal barrier12–15. The instability of the gut microbiota and the immaturity of the immune system make newborns particularly...
(PCs) accounted for 91% of the total variance. The PC1 mainly reflects the differences between the control and 0.5% mucin groups, indicating a significant impact of mucin addition on the growth ofA. muciniphila(Fig.2A). Venn diagram and volcano plots indicated that higher mucin addition ...
Remarkably, both our Golgi proteomics as well as our glycomic analysis converge on the glycosyltransferase B3GNT6. A total of 10 glycosyltransferases were found to be decreased in common between TVP23B and YIPF6-deficient Golgi, speaking to the broad affect TVP23B has in regulating intestinal glyc...