Accurate locomotor activity profiles of group-housed mice derived from home cage monitoring datadoi:10.3389/fnins.2024.1456307ALZHEIMER'S diseaseANIMAL welfareMUSCLE massMETABOLIC disordersLABORATORY animalsIntroduction: Holistic phenotyping of rodent models is increasing, with a growing ...
20,34, which poses a conflict between nocturnal foraging and light aversion within their home-cage and without human presence. WT mice responded acutely with sharplyincreasedactivity followed by sustained immobility within shelters. In comparison, a relatively blunted locomotor suppression response was se...
Figure8illustrates the distribution of behavioral, physiological, and external appearance-related parameters between 1974 and 2020. Categories of behavioral parameters (Fig.8A; a range of behaviors were subsumed under a category) that have been investigated throughout were locomotor activity, feeding, so...
Here, female Mecp2Stop mice [1] were characterised at mild symptomatic conditions in tests for anxiety (open field, elevated plus maze) and home cage observation systems for food intake, locomotor activity and circadian rhythms. Aged 8–9 months, Mecp2Stop mice presented with heightened body ...
Although such systems can be used effectively to monitor locomotor activity and perform operant conditioning, they cannot be used to study home- cage behaviours such as grooming, hanging, jumping and smaller movements (termed 'micromovements' below). Visual analysis is a potentially powerful ...
Thus, the here presented home cage activity counter can be used for the measurement of basal home cage locomotor activity.K.GaneaandC.LieblandV.SterlemannandM.B.EBSCO_AspJournal of Neuroscience MethodsGanea K, Liebl C, Sterlemann V, Muller MB, Schmidt MV. Phar- macological validation of...
Home cage observationsBehavioural phenotypingMiceThis paper introduces automated observations in a modular home cage system as a tool to measure the effects of wheel running on the time distribution and daily organization of cage floor locomotor activity in female C57BL/6 mice. Mice (n = 16)...
Muscle strength, anxiety-like behavior, and locomotor activity were assessed by a battery of tests (wire hang, suspension, grip strength, rotarod, elevated-plus maze, and open field tests). Mice prevented from climbing the wire grid during postnatal development displayed lower muscle strength than...
Behavioral sensitization was evaluated by the quantification of open-field locomotor activity after AMP or ETOH challenge injection, respectively. In both experiments, behavioral sensitization was potentiated in HOM-HC maintained animals. These results suggest that the behavioral sensitization phenomenon can ...
In the OF test, CSDS reduced total locomotion in both genotypes, whereas KO animals displayed greatly increased locomotor activity irrespective of the stress condition (Figure 2d). In the SA test, WT animals displayed a reduced social interaction ratio when under the effects of CSDS (po0.05), ...