CO is one of its reaction products that has been recognized as a natural physiological regulator, influencing intracellular signalling pathways and suppressing inflammatory responses [67]. It can also regulate fibroblast proliferation, thereby protecting against organ fibrosis. Some studies have demonstrated...
The redox-insensitive Neh6 domain is characterized by the ubiquity of serine residues with DSGIS and DSAPGS motifs. The Neh6 structural domain provides a phosphorylation-dependent binding platform for β-TrCP and is responsible for the regulation of Nrf2 degradation through a mechanism independent of...