[12]Su Y, Cui J, Xu D, et al. p16(INK4a) status and survival benefit of EGFR inhibitors in head and neck squamous cell cancer: A systematic review and meta-analysis. Crit Rev Oncol Hematol. 2018 Apr;124:11-20...
The nanomedicine is emerging as a promising strategy to achieve maximal anti-tumor effect in cancer therapy. In this review, we summarize some important signaling pathways and present the current and potential roles of various nanomaterial drug-delivery formulations in HNSCC treatment, aiming to ...
Secondary end points included duration of response, progression-free survival, central review–assessed ORR, overall survival, pharmacokinetics, immunogenicity, and biomarkers. In the safety-evaluable population (n = 45), any-grade treatment-emergent adverse effects (TEAEs) occurred in all patien...
The role of PD-1/PD-L1 axis in treg development and function: implications for cancer immunotherapy[J]. Onco Targets Ther, 2019, 12: 8437-8445. doi: 10.2147/OTT.S221340. https://www.dovepress.com/oncotargets-and-therapy-journal Cited in this article [2] [7] Zou W, Wolchok JD, ...
2. Cohen EEW, Fayette J, Daste A, et al. Clinical activity of MCLA-158 (petosemtamab), an IgG1 bispecific antibody targeting EGFR and LGR5, in advanced head and neck squamous cell carcinoma (HNSCC). Clin Cancer Res. 2023;83(suppl 8):CT012. doi:10.1158/1538-7445.AM2023-CT012Recent...
A systematic review of 13 articles plus 4 meeting presentations was conducted to determine if ICI therapy was safe and efficacious in patients with HIV infection and advanced stage cancer, including NSCLC, melanoma and Kaposi sarcoma. This analysis was comprised of 73 patients from 13 articles (11...
Cancer Imaging volume 20, Article number: 56 (2020) Cite this article 5249 Accesses Metrics details Abstract Background To determine the usefulness of Diffusion Weighted Imaging (DWI) derived from PET/MRI in discriminating normal from metastatic lymph nodes and the correlation between the metastatic ...
Cancer Gene Therapy volume 30, pages 182–191 (2023)Cite this article 707 Accesses 1 Altmetric Metrics details Abstract Glycosylation change is one of the landmark events of tumor occurrence and development, and tumor cells may be inhibited by regulating the aberrant expression of glycosyltransferases...
These mechanisms include inhibiting EGFR-dependent signaling, binding to LGR5 to facilitate EGFR internalization and degradation in cancer cells, and prompting antibody-dependent cell-mediated cytotoxicity and antibody-dependent cellular phagocytosis activity. In the...
It is well-known that cancer-associated fibroblasts (CAFs) are involved in the desmoplastic responses in Head and Neck Squamous Cell Carcinoma (HNSCC). CAFs are pivotal in the tumor microenvironment (TME) molding, and exert a profound influence on tumor