近日,华中科技大学同济医学院生殖健康研究所袁水桥教授团队在Advanced Science杂志在线发表了题为hnRNPC functions with HuR to regulate alternative splicing in an m6A-dependent manner and is essential for meiosis的研究论文。该研究发现核...
However, the function and mechanism of heterogeneous nuclear ribonucleoprotein C (HNRNPC), an RNA-binding protein and m6A reader in gliomas remains to be comprehensively and extensively explored. Herein, we found that HNRNPC mRNA and protein overexpression were associated with a poor prognosis for ...
通过单变量和多变量 cox 回归分析,在 13 个 m6A 相关基因中,只有异质核核糖核蛋白 C (HNRNPC) 可能是独立的生物标志物和 OSCC 中不利的总生存期。功能研究表明,HNRNPC 的过表达通过上皮间质转化 (EMT) 促进了 OSCC 的癌变。总之,建立了OSCC中m6A相关基因的风险模型。随后,HNRNPC被证明可促进OSCC的致癌作用,是...
Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells and plays an important role in the occurrence and development of human tumors. However, the functi
m6A RNA modification is a common abundant posttranscriptional modification of mRNAs occurring in cancer growth and progression. Accumulated evidence has proved that HNRNPC, which acts as a m6A reader...
一个HNRNPC四聚体能结合230-240个核苷酸。三个HNRNPC四聚体能结合700个核苷酸。hnRNP还在剪接体组装的早期步骤中发挥作用,相关研究指出,N6-甲基腺苷(m6A可以通过相应的读取蛋白改变mRNA或长链非编码RNA(lncRNA)的局部结构,促进HNRNPC的结合,从而调节mRNA剪接形式[2]。
目的:研究m6A阅读器HNRNPC通过增强Lnc RNAAC145207.5的稳定性调控其在结直肠癌细胞中的表达,并可能经Nrf2/GPX4信号轴介导铁死亡的方式影响结直肠癌的发生发展.方法:1.提取筛选分析TCGA-GTEx-COADREAD数据库中结直肠癌和对照组表达谱,找出具有显著性差异表达的Lnc RNA.ROC感受态曲线预测其成为肿瘤标志物的可能性.RT-q...
EMTBackground: M6A is the most widespread RNA internal modification that contributes to the transcription of RNA-mediated genes. Increasing evidence suggest that mHuang, GuangzhaoWu, Qing-qingZheng, Ze-nanShao, Ting-ruChen, Yue-chuanZeng, Wei-seng...
Conclusions:M6A regulator HNRNPC, a predictor of prognosis and immunotherapy response based on bioinformatics analysis, is related to proliferation and invasion of NSCLC cells. 展开 关键词: HNRNPC Invasion NSCLC Proliferation m6A methylation DOI: 10.1186/s12931-022-02227-y 年份: 2022 ...
humanWB Nat Struct Mol Biol Alternative polyadenylation by sequential activation of distal and proximal PolyA sites. humanWB Adv Sci (Weinh) m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia ...