hnrnp a18(Heterogeneous Nuclear Ribonucleoprotein A18)可能指的是一种核不均一核糖核蛋白A18,这类蛋白在生物体内主要参与RNA的代谢过程,包括RNA的剪接、转运和翻译调控等。它们对于维持细胞正常的生理功能至关重要。 如果您是在学术研究或者生物医学领域遇到这个术语,以下是一些建议: 查阅专业文献:可以通过学术搜索引擎(...
After phosphorylation, hnRNP A18 translocates from the nucleus to the cytosol where it interacts with pro-survival mRNA transcripts for proteins such as hypoxia inducible factor 1 alpha and CTLA-4. Both the hypoxic cellular response and modulation of immune checkpoints by cancer cells promote ...
Cold-Inducible Rna-Binding Protein Cirp/Hnrnp A18 Regulates Telomerase Activity in a Temperature-Dependent Manner 类型: 作者:Zhang, Y., Wu, Y., Mao, P., Li, F., Han, X., Zhang, Y., Jiang, S., Chen, Y., Huang, J., Liu, D., Zhao, Y., Ma, W. & Songyang, Z. 期刊:Nuclei...
Toward the development of hnRNP A18 inhibitors, the X-ray crystal structure of the hnRNP A18 RNA recognition motif (RRM) was solved and used in the design of inhibitors for hnRNP A18 that disrupt RNA binding with the RRM. Initial inhibitors were identified through the Site Identified Ligand ...
Phosphorylation of hnRNP A18Ruiqing, Yang
Carrier, 2001 The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. J Biol Chem 276:47277-47284.Yang C, Carrier F. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. J ...
Investigation of the Impact of Post-Translational Modifications of HNRNP A18 on Small Molecule Inhibitorsdoi:10.1016/j.bpj.2019.11.450Katherine CoburnEduardo Solano-GonzalezBraden RothPaul T. WilderKristen VarneyFrance CarrierDavid J. WeberBiophysical Journal...
The UV-inducible RNA-binding Protein A18 (A18 hnRNP) Plays a Protective Role in the Genotoxic Stress Responsedoi:10.1074/jbc.M105396200CL YangFrance Carrier
细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知.这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1.EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的...
韩娟;李为民;唐凤鸣;蒲丹;陈文彬.hnRNP B1对人肺癌A549细胞DNA-PK活性及细胞周期、凋亡的影响.四川大学学报:医学版.2008.815-818韩娟,李为民,唐凤鸣,蒲丹,陈文彬.  hnRNP B1对人肺癌A549细胞DNA-PK活性及细胞周期、凋亡的影响[J]. 四川大学学报(医学版). 2008(05)...