distribution at diagnosis of sporadic patients was significantly higher than that of FAP and HNPCC patients (median 60 years vs. 43 and 49 years; p vs. 14% in the FAP group and 13% in the sporadic-cancer group. In the sporadic group, 51% were early-stage cancers (Dukes A or B...
Familial colorectal cancer syndromes, HNPCC and familial adenomatous polyposis (FAP), account for around 3% of all colorectal cancer cases; however, approximately 20% show familial inheritance of which there is no known genetic cause [2]. Mutations of the genes involved in the mismatch repair ...