在当时,许多研究机构和制药公司都在积极寻找降血脂药物,而已知研究表明,胆固醇合成的限速酶是HMG-CoA还原酶(羟甲基戊二酰单酰辅酶A还原酶)。只有控制住这个酶,才能阻断胆固醇的合成。 既然HMG-CoA还原酶是抑制胆固醇合成的关键靶点,那么,谁先寻找到它的抑制...
那啥是HMGCoA还原酶呢?哎呀呀,简单来说,它是一种酶!这酶可不得了呀!它参与了胆固醇的合成过程哟! HMGCoA还原酶能把HMGCoA转化为甲羟戊酸,这甲羟戊酸又是合成胆固醇的重要前体物质呢!哎呀,是不是有点复杂?别着急,慢慢听我讲哈。 为啥要关注这个HMGCoA还原酶呀?因为它和好多健康问题都有关系呢!比如说,胆固醇...
In this context, methyl-尾-cyclodextrin (MCD), a membrane cholesterol depletor, or mevastatin, an HMG-CoA reductase inhibitor, or N-acetyl cysteine, ... KK Biswas,KP Sarker,K Abeyama,... - 《Hepatology》 被引量: 245发表: 2003年 Lipoprotein-X fails to inhibit hydroxymethylglutaryl coenzyme...
Here, we show that cholesterol-lowering agents, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, protect against cerebral injury by a previously unidentified mechanism involving the selective up-regulation of endothelial NO synthase (eNOS). Prophylactic treatment with HMG-CoA reductase ...
HMG,是促使卵泡长大的,书名叫尿促,是绝经妇女的尿液提取物吧。HCG,是促使成熟卵泡排出的,书名叫绒促。一般HMG是在用克罗米芬等西药片无法使得卵泡长大的情况下,打针是卵泡成熟长大。当卵泡长大到成熟卵泡,即20*18左右,医生给开HCG,来促使卵泡排出。 匿名用户 2013-08-20 18:36 宝宝知道提示您:回答为网友贡献,...
Conformation and recognition by HMG-domain proteins as well as excision repair of DNA monofunctional adducts containing a novel antitumor bifunctional platinum complexKašpárkováJanaZehnulova,J., Kasparkova,J., Farrell,N. and Brabec,V. (2001) Conformation, recognition by HMG-domain proteins and ...
The recent development of several specific competitive inhibitors of the ratelimiting enzyme in cholesterol biosynthesis (3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG CoA reductase) has opened up an important new avenue of therapy for patients with hypercholesterolemia who are not responsive to ...
HMG-CoA还原酶抑制药临床用于A.杂合子家族性高胆固醇血症B.原发性高胆固醇血症C.Ⅲ型高脂蛋白血症D.糖尿病和肾病性高脂血症E.伴有心衰的高脂血症
Most of the therapeutic benefit results from a dominant, myeloid-biased cell clone, in which the integrated vector causes transcriptional activation of HMGA2 in erythroid cells with further increased expression of a truncated HMGA2 mRNA insensitive to degradation by let-7 microRNAs. The clonal ...
3一羟基一3一甲基戊二酸辅酶A(3一切企.Xy-3-methylglutaryl-coenzymeA,HMG-CoA)还原酶抑制剂是一类新型降血脂药物,为临床防治动脉粥样硬化首选药.目前已用于临床有5种:洛伐他汀(lovastatin,默克公司创制);辛伐他汀(simvastatin,默克公司创制);普伐他汀(pravastatin,日本三井公司创制);氟伐他汀(flulatatin,瑞士sandoz...