psoriasisObjective: Anti-high-mobility group box 1 (HMGB1) is involved in the pathogenesis of many inflammatory and autoimmune diseases, including psoriasis. The present study aimed to investigate the therapeutic effects of HMGB1 monoclonal antibody (mAb) in keratin 14 (K14)-vascular endothelial ...
Furthermore, in a recent clinical trial, Coleman et al.166 used a monoclonal antibody (MABp1) targeting IL-1α for the treatment of psoriasis. The role of IL-1α in cardiovascular diseases is not restricted to its proinflammatory function following myocardial infarc- tion. Indeed, mounting ...
HMGB1 Inhibitor Effectively Alleviates Psoriasis-Like Lesions and Inflammatory Cytokines in K14-VEGF Transgenic Mice 2023, International Journal of Dermatology and Venereology Direct conversion of a general antibody to its catalytic antibody and corresponding applications —Importance and role of Pro95 in CD...
The drug is also used to treat specific cutaneous inflammation, such as erythrodermic psoriasis and atopic dermatitis [18,19]. In addition, the clinical use of GLR is now considered for the treatment of depression [20], Parkinson's disease [21] and different cancers, such as hepatocellular ...
Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics It presents molecular targets such as high-mobility group box-1 (HMGB1), dual-specificity phosphatase-1 (DUSP1), and the aryl hydrocarbon receptor (AhR... GL Yu,Y Jung,HK Choi,... - 《Inte...
Objectives: This study tested the hypothesis that a differential innate immune antimicrobial peptide (AMP) profile was evident between the skin and joints in psoriasis and psoriatic arthritis (PsA) and that PsA synovitis may have a disti... H Bierkarre,J Harder,R Cuthbert,... - 《Scandinavian...
HMGB1 is also involved in various skin disorders, such as psoriasis, acne vulgaris, atopic dermatitis, and vitiligo. Understanding the function of HMGB1 in skin diseases is still an area of active research, and there are potential therapeutic approaches targeting HMGB1....
Increased HMGB1 serum levels and altered HMGB1 expression in patients with psoriasis vulgaris. Arch Dermatol Res 2013; 305: 263-267.Chen T, Guo ZP, Li L, Wang L, Jia RZ, Cao N, Qin S, Li MM. Increased HMGB1 serum levels and altered HMGB1 expression in patients with psoriasis vulgaris....
The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) ...