elegans. We found that HLH-30 elevated the transcript levels of v-ATPase and cathepsin, thus enhancing lysosomal activity. This led to an increase in autophagic flux, facilitating more pronounced degradation of Aβ. Moreover, HLH-30 reduced the level of ROS induction by Aβ ...
Here we identify MXL-3 and HLH-30 (TFEB orthologue) [corrected] as transcriptional switches coupling lysosomal lipolysis and autophagy to nutrient availability and controlling fat storage and ageing in Caenorhabditis elegans. Transcriptional coupling of lysosomal lipolysis and autophagy to nutrients is ...
Here we show that the predicted TFEB orthologue HLH-30 regulates autophagy in Caenorhabditis elegans and, in addition, has a key role in lifespan determination. We demonstrate that hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models...
elegans. However, the mechanism whereby G3PP activation extends healthspan and lifespan, particularly under glucotoxicity, remained unknown. Here, we show that the overexpression of the C. elegans G3PP homolog, PGPH-2, decreases fat levels and mimics, in part, the beneficial effects of calorie...
elegans. Thus, the males appear to be equipped with enhanced HLH-30/TFEB-mediated autophagy, which increases pathogen resistance, and this may functionally prolong mate-searching ability with reduced risk of infection.SohnKwonLeeKimLeeLeeJung
HLH-30/TFEB mediates sexual dimorphism in immunity in Caenorhabditis elegansJooyeon SohnSujeong KwonGee-Yoon LeeSieun S. KimYujin LeeJongsun LeeYoonji JungSeokjin HamHae-Eun H. ParkSangsoon Park
elegans. While various tissues contribute differentially to organismal lifespan, neurons are particularly interesting as they can mediate adaptive response to environmental and proteostatic stresses. Using carefully-designed neuronal-specific reconstitution of HLH-30 in loss of function hlh-30 mutants, we ...
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Autophagy 2016; 13(2):371-385:1-15; PMID:27875098; https://doi.org/10.1080/15548627.2016.1256933...
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Louis R. Lapierre,C.Daniel De Magalhaes Filho,Philip R.McQuary,et al. Nature . 2013Lapierre LR, De Magalhaes Filho CD, McQuary PR, et al. The TFEB orthologue HLH-30 regulates autophagy and ...
elegans by employing genetic, transgenic, and molecular approaches. We found that FMO-2 is important for host defense against S. aureus infection, and its induction during S. aureus infection is controlled by two transcription factors, HLH-30 and NHR-49 (C. elegans ortholog of the mammalian ...