Inhibitor of DNA binding protein 3 (ID3) has long been characterized as an oncogene that implicates its functional role through its Helix鈥揕oop鈥揌elix (HLH) domain upon protein鈥損rotein interaction. An insight into the dimerization brought by this domain helps in identifying the key residues ...
The signature HLH domain normally mediates protein dimerization and is required for DNA binding. Deletion of the HLH domain in HLH-11 did not affect its nuclear localization (Supplementary Fig. 2e), but the mutant protein failed to suppress the induction of the Plipl-3::gfp or Pacs-2::gfp...
The protein Id: a negative regulator of helix-loop-helix DNA binding proteins Cell, 61 (1990), pp. 49-59 View PDFView articleView in ScopusGoogle Scholar Bhattacharya and Baker, 2009 A. Bhattacharya, N.E. Baker The HLH protein Extramacrochaetae is required for R7 cell and cone cell fate...
[21] Blackwood EM, Eisenman RN (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251: 1211–1217. doi: 10.1126/science.2006410 [22] Prendergast GC, Lawe D, Ziff EB (1991) Association of Myn, the murine homolog of max,...
The ili1-D mutant overexpresses an HLH protein homologous to Arabidopsis thaliana Paclobutrazol Resistance1 (PRE1) and the human Inhibitor of DNA binding proteins. Overexpression and RNA interference suppression of ILI1 increase and reduce, respectively, rice laminar inclination, confirming a positive ...
疾病。提取外周血DNA,于d删码区设计3对特异性引物行PCR扩增,先用变性高 效液相色谱法(DenaturingHi曲一PerformanceLiquidChromatography,DHPLC)检测是 否存在杂合双链。如果检测出杂合双链,再用PCR产物直接测序寻找突变位点。 结果:在100例POF患者中,我们新发现了GDF9编码区3个位点的非同义突变: ...
[9] Blackwood EM, Eisenman RN (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251: 1211–1217. [10] Gu W, Cechova K, Tassi V, Dalla-Favera R (1993) Opposite regulation of gene transcription and cell proliferation by ...
Gene ontology analysis of genes upregulated in pgph-2 o/e animals in comparison to WT under 2% excess glucose conditions also revealed similar changes as without glucose such as ‘innate immune response’, ‘carbohydrate binding’, ‘unfolded protein response’, and ‘stress response’ genes, ...
Mutational analysis suggests that this interaction occurs via the basic region of muscle b-HLH proteins and the DNA-binding domain of RA-receptors and is important for functional interactions between these two families of transcription factors. In conclusion, these results highlight novel interactions ...
The HLH domain, also called the Pointed (PNT) domain, mediates polymerization of the TEL molecules or heterodimeriza-tion with other ETS family members, such as FLI-1 or TEL2 , The ETS domain is necessary for specific DNA binding to the ETS-binding consensus site (EBS), GGAA/T . ...