The semidominant Mi-b mutation identifies a role for the HLH domain in DNA binding in addition to its role in protein dimerization. EMBO J. 15, 6280-6289.The semidominant Mi (b) mutationidentifies a role for the HLH domain in DNA binding in addition to its role inprotein dimerization. ...
The signature HLH domain normally mediates protein dimerization and is required for DNA binding. Deletion of the HLH domain in HLH-11 did not affect its nuclear localization (Supplementary Fig. 2e), but the mutant protein failed to suppress the induction of the Plipl-3::gfp or Pacs-2::gfp...
The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete–scute protein complexes Development, 113 (1991), pp. 245-255 CrossrefView in ScopusGoogle Scholar Watt et al., 2008 Watt F.M., Estrach S., Amber C.A. Epidermal Notch signalling: differe...
Boxes, exons; lines, introns; region encoding bHLH DNA-binding domain, dark grey. Bracketed region is deleted in hlh-2(tm1768) deletion/insertion allele. (B) The HLH-2 ORF. The predicted hlh-2(tm1768) protein harbors a 93 aa deletion and six amino acid insertion of novel sequence in ...
[9] Blackwood EM, Eisenman RN (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251: 1211–1217. [10] Gu W, Cechova K, Tassi V, Dalla-Favera R (1993) Opposite regulation of gene transcription and cell proliferation by ...
Gene ontology analysis of genes upregulated in pgph-2 o/e animals in comparison to WT under 2% excess glucose conditions also revealed similar changes as without glucose such as ‘innate immune response’, ‘carbohydrate binding’, ‘unfolded protein response’, and ‘stress response’ genes, ...
In the HLH-LZ protein family, the helix-loop-helix DNA-binding dimerization domain is followed in the sequence by a leucine zipper motif. The precise function of this second dimerization domain is still unclear, since the HLH motif of a subset of this family has been shown to be necessary ...
- 2008 () Citation Context ...ique DNA binding domain (DBD); an immunoglobulin / plexin / transcription (IPT) domain putatively involved in both DNA/protein and protein/protein interactions; and an atypical HLH dimerization motif =-=[1,2,3]-=-. coe genes have been identified in the ...
bHLH protein functions are also modulated by another class of broadly expressed HLH proteins or Id-proteins [Extramacrochaetae (Emc), Id1-4], which lack the DNA-binding basic domain and inhibit bHLH transcription factors by forming inactive heterodimers.;We discovered a novel cross-interacting ...
Mutational analysis suggests that this interaction occurs via the basic region of muscle b-HLH proteins and the DNA-binding domain of RA-receptors and is important for functional interactions between these two families of transcription factors. In conclusion, these results highlight novel interactions ...