Peripheral blood smear was positive for significant presence of schistocytes. Despite her lack of splenomegaly, she met 7 out of 8 criteria for HLH: fever, cytopenia affecting at least 2 of 3 lineages, hypertriglyceridemia (636 mg/dL), hemophagocytosis in bone marrow, low NK-cell activity, ...
Blood. 2011;118:4041-4052.第53页/共89页HLH相关实验室检查和评价必须紧密结合临床HLH诊断的起点、线索和重要依据除符合HLH诊断标准外,必须重点考虑HLH的原因或原发疾病男性患者,反复感染、阳性家族史,考虑XLP肿瘤相关性HLH应注重肿瘤本身的临床表现第54页/共89页第55页/共89页第56页/共89页血液常规检查全血...
Methods The results of the bone marrow smear of patients confirmed with HLHin pediatric department from December 2003 to December 2009 were retrospectively reviewed,and the clinical data of patients hospitalized in the same period being identified with hemophagocytosis but excluded HLH were analysed.The...
(T450M)目前十二页\总数八十八页\编于十三点JordanMB,etal.HowItreatHLH.Blood.2011;118:4041-4052.fHLH中以Perforin基因突变最为常见fHLH绝大部分2岁前发病而诊断,尤其是在EBV感染率高的发展中国家和地区目前十三页\总数八十八页\编于十三点不同国家和地区fHLH发病率有所不同,sHLH发病率差异更大Hunter等1991...
Henter JI, Horne A, AricoM, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka Pediatr Blood Cancer. 2007;48(2):124 3. Takahashi N, Chubachi A, Kume M, et al. A clinical analysis of 52 adult patients with hemophagocytic syndrome: the ...
Blood. 2011;118:4041-4052. 必须紧密结合临床 HLH诊断的起点、线索和重要依据 除符合HLH诊断标准外,必须重点考虑HLH的原因或原发疾病 男性患者,反复感染、阳性家族史,考虑XLP 肿瘤相关性HLH应注重肿瘤本身的临床表现 HLH相关实验室检查和评价 全血细胞减少(pancytopenia) 最重要血液学特征,但无特异性 进行性加重,...
A peripheral blood smear showed lymphocytosis with many reactive lymphocytes, anemia, and thrombocytopenia. Laboratory studies showed elevated ferritin, triglycerides, and soluble IL-2/CD25. A cervical lymph node biopsy demonstrated an EBV-positive, reactive B-immunoblast proliferation with large atypical ...
Peripheral smear showed burr cells, no schisctocytes, Low platelets. WBC morphology was normal. He required ventilatory support along with two Vasopressors inspite aggressive fluid resuscitation. A CT of abdomen and pelvis did not reveal any source of infection. His Lactate went up to 4.5. ...
Blood. 2011;118:4041-4052.;必须紧密结合临床 HLH诊断的起点、线索和重要依据除符合HLH诊断标准外,必须重点考虑HLH的原因或原发疾病男性患者,反复感染、阳性家族史,考虑XLP 肿瘤相关性HLH应注重肿瘤本身的临床表现;全血细胞减少(pancytopenia)最重要血液学特征,但无特异性进行性加重,血小板和中性粒细胞降低程度重、...