抗CD45抗体可以抑制PHA或CD3交联所介导的T细胞增殖,还可抑制NK或细胞毒性T细胞对靶细胞的杀伤,抑制经CD2、CD3以及CD8膜分子介导的信号转导作用。白细胞共同抗原是五种或更多的高分子量糖蛋白组成的蛋白家族,主要位于白细胞表面,包括T、B淋巴细胞、多形核白细胞、单核细胞等,而在红细胞、血小板及非造血系统中不...
因此,可应用于表位肽疫苗的制备,或应用于诱导产生CD8+T细胞表位肽特异性的细胞毒性T细胞CTL,或应用于制备HLA‑E*0103表位肽‑复合物四聚体,在HFRS特异性免疫治疗领域中有着良好的开发应用前景。 专利权项:1.一类HLA-E*0103限制性HTNV结构蛋白特异性CD8+T细胞表位肽,其特征在于,所述表位肽的氨基酸序列如SEQID...
肾移植患者外周血人巨细胞病毒特异性CD8^+T淋巴细胞频率及其γ干扰素分泌功能的初步研究 目的研究肾移植患者外周血人巨细胞病毒(HCMV)特异性细胞毒T淋巴细胞(CTL)的频率 及其γ干扰素(IFN-γ)分泌功能,以期探讨HCMV活化感染的免疫学机制.方法选取HCMV血清学... 杨瑞锋,徐国宾,吴煦,... - 《中华检验医学杂志》 ...
Methods:We analyzed by flow cytometry hCMV-specific immune responses driven by peripheral blood antigen-presenting cells (APC) and CD4 memory T-cells at both the cellular and soluble levels, and their cooperation in priming and sustaining the effector function of specific CD8 T cells in adult ...
CD8 + T cells from C57BL/6(B6) mice show cytotoxicity to B cell blasts prepared from syngeneic transgenic mice expressing HLA-DQ6 molecules in a mouse MHC class I H-2D b restricted manner. Although these results suggest that CD8 + T cells recognize peptides derived from DQ6 molecule bound...
The CD8+ cytotoxic T cell clone 1R35 and the CD4+ cytotoxic and proliferative T cell clone R416 were derived by limiting dilution culture from the PBMC of a female aplastic anemia patient who had undergone multiple transfusions and who had rejected HLA-identical male bone marrow (17, 8). Bo...
Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play ...
Persistent Survival of Prevalent Clonotypes within an Immunodominant HIV Gag-Specific CD8+ T Cell Response CD8+ T cells play a significant role in the control of HIV replication, yet the associated qualitative and quantitative factors that determine the outcome ... DJ Van Bockel,DA Price,ML Munie...
further confirming the presence of circulating antigen experienced cytotoxic CD4(+) T cells in hCMV-seropositive individuals. Moreover, we observed that both CD4+ and CD8+ hCMV-specific T-cells included relatively restricted numbers of TCR-V beta family members. Interestingly, we found a ...