HLA—DRB.*1501等位基因的频率较普通人群高,对环孢菌 素A(CsA)治疗敏感且具有依赖性。由于HIA各等位基因存 在较大的种族和地域差异,在汉族人群中是否可以据此预测 CsA对从的疗效,目前报道较少。我们用PCR-SSO及PCR. SSP技术检测山东日照地区汉族从患者中该等位基因,观 ...
CONCLUSION: The results suggest that HLA-DRB1*1501 allele may be a risk indicator for the susceptibility to severe CP in Han nationality (P<0.05). The HLA-DRB1*1501 homozygote genotype was associated significantly with severe CP(P<0.05).張韶君...
摘要:目的 从基因水平探讨新疆哈萨克族食管鳞状细胞癌HLA-DRB1和DQB1等位基因的遗传易感性,为寻找哈萨克族食管鳞状细胞癌的易感基因提供线索.方法 运用序列特异性引物聚合酶链反应(PCR-SSP)技术,检测新疆哈萨克族食管鳞状细胞癌200例、正常食管黏膜177例HLA-DRB1 *0901、1501和DQB1 *0301、0602等位基因的分布.结果 新...
HLA—DRB1 ＊1501和DQB1 ＊0602与新疆哈萨克族HPV感染及食管癌发生的相关性研究
结果伴有猝倒发作的发作性睡病患者组的HLA-DRB1*1501-HLA-DQB1*0602单体型的阳性率为30%(6/18),无典型猝倒发作的发作性睡病患者组的HLA-DRB1*1501-HLA-DQB1*0602单体型的阳性率为29.2%(7/24),正常对照组的HLA-DRB1*1501-HLA-DQB1*0602单体型的阳性率为9%(5/55),猝倒发作的发作性睡病患者组的HLA-DRB1...
Susceptibility to multiple sclerosis is associated with the human histocompatibility leukocyte antigen (HLA)-DR2 (DRB1*1501) haplotype. The structure of HLA-DR2 was determined with a bound peptide from human myelin basic protein (MBP) that is immunodominant for human MBP-specific T cells. Residues...
Good response to cyclosporine therapy in patients with myelodysplastic syndromes having the HLA-DRB1*1501 allele. Leukemia 2000; 14(2): 344-346.Okamoto T,Okada M,Yamada S,et al.Good response to cyclospo-rine therapy in patients with myelodysplastic syndromes having the HLA-DRB1*1501allele. ...
抗甲状腺药物引起Graves病病人白细胞减少与HLA-DRB1 ＊08032及-DRB1 ＊1501等位基因相关性 维普资讯 http://www.cqvip.com
Alexander. Identification of hla-drb1*1501-restricted t-cell epitopes from human prostatic acid phosphatase. Prostate, 67:1019-1028, 2007.Klyushnenkova, E.N.; Alexander, R.B. CD4 T-Cell-mediated immune response to prostatic proteins in HLA-DRB1*1503 transgenic mice and identification of a ...
Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D Multiple sclerosis (MS) is a complex trait in which allelic variation in the MHC class II region exerts the single strongest effect on genetic risk. Epidem... SV Ramagopalan,NJ Maugeri...