方法:用 SYFPEITHI 软件预测 HPV18 E7抗原 HLA-DRB1*0301 限制性 Th 表位, 候选表位分别命名为 P1、 P2、 P3, 以固相多肽合成技术合成, 并运用 HPLC 进行纯化和质谱法(MS)鉴定。 以密度梯度法分离 HLA-DRB1*0301 阳性健康人外周血单核细胞(PBMC), 合成肽刺激 PBMC, 用 5-溴脱氧尿嘧啶核苷(Brdu)检测淋巴...
Graves病遗传易感HIJA-DRB1*0301等位基因目的探讨HLA-DRB1*0301等位基因在粤西湛江沿海地区Graves病(GD)发病中的作用.方法选取65例初诊GD病人和正常对照50例并采用多聚酶链反应.序列特异性引物(PCR.SSP)技术检测HLA-DRB1*0301等位基因的表达频率.结果初诊GD病人HLA-DRB1*0301等位基因的表_达频率显著高于正常对照组(P...
HLA-DRB1*03:01/HLA-DRB1*04:01-positive patients had a higher median IAIHG score than HLA-DRB1*03:01/HLA-DRB1*04:01-negative patients (P<0.001). We did not observe associations between HLA alleles and alanine transaminase levels (HLA-DRB1*03:01: P=0.2; HLA-DRB1*04:01; P=0.5); ...
DRB1*12DQ基因单倍体英国抗原女阴HLAHIA-DR序列特异性引物Lichen sclerosus (LS) is considered to have an immunogenetic background. Several small studies, using serological typing, have reported that HLA-DR11, DR12, and DQ7 were increased in LS, with DR17 less frequent. This study aimed to ...
Vu Trieu An, Tran Thi Chich; Ngyuyen Thanh Thuy; Le Monnier De Gouville, Isabelle; Sanchez Mazas, Alicia; Djoulah, Sami; Hors, Jacques, 1996: The HLA DRB1*1202-DQB1*0301 haplotype reveals an unusually high frequency in the Vietnamese population from Hanoi...
HLA-DRB1*0301 and DQA1*0501 in RAAuranofin is an oral gold preparation used in the treatment of rheumatoid arthritis (RA). During treatment, proteinuria has been reported in approximately 3% of patients.1 In a few cases in which renal biopsies were performed, a membranous nephropathy was ...
HLA-DRB1*03:01 is the strongest genetic modifier of disease severity in AIH.Genes and Immunity advance online publication, 22 January 2015; doi:10.1038/gene.2014.82.doi:10.1016/S0016-5085(15)33445-4Gerven, N.M. vanBoer, Y.S. de
A silent mutation in HLA- DRBl*O301 can affect oligotyping. Tissue Antigens 1992: 40: 150-152.Eberle M, Baxter-Lowe LA. A silent mutation in HLA-DRB1*0301 can affect oligotyping. Tissue Antigens 1992; 40: 150–2.I Eberle M, Baxter-Lowe LA: A silent mutation in HLA- DRBl*O301 ...
A silent mutation in HLA- DRBl*O301 can affect oligotyping. Tissue Antigens 1992: 40: 150-152.Eberle M, Baxter-Lowe LA. A silent mutation in HLA-DRB1*0301 can affect oligotyping. Tissue Antigens 1992; 40: 150–2.I Eberle M, Baxter-Lowe LA: A silent mutation in HLA- DRBl*O301 ...
Jung, C., Kalbus, M., Fleckenstein, B., Melms, A., Jung, G., Wiesmuller, K.H., 1998. New ligands for HLA DRB1*0301 by random selection of favourable amino acids ranked by competition studies with undecapeptide amide sublibraries. J Immunol Methods 219, 139-149....