Cell—神经免疫和炎症再获突破!!HLA-DR15肽段经B细胞提呈是MS中自身反应性T细胞活化的重要环节2020 10/28 神经科学临床和基础 个人 + 分享 神经科学临床和基础 A- A+ 本文由作者自行上传,并且作者对本文图文涉及知识产权负全部责任。如有侵权请及时联系(邮箱:guikequan@hmkx.cn)关键词: 细胞炎症免疫 ...
Background: The HLA-DR15 extended haplotype HLA-DRB1*1.5:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial ...
Multiple sclerosis (MS) has been associated with the human leukocyte antigen DR15 allele in Caucasians of North and Central European origin. However, the relative effect of the DR15 homozygous and the DR15 heterozygous genotypes on the disease susceptibility is unclear. Based upon results from thre...
HLA-A*0301 has been shown to increase the risk of developing MS in addition to HLA-DR15 [34] or independently of the HLA-DRB1*15, DQB1*06 [35,36]. In contrast, the HLA-A*0201 allele decreases the risk of developing MS [37] and reduces the risk for DRB1*15, DQB1*06 carrier ...
The purpose of this case–control study was to evaluate the frequencies and potential genetic susceptibility of the −330 IL2 T and G alleles and HLA-DRB1*1501 allele in Iranian patients with multiple sclerosis (MS) compared to healthy controls. Two hundred and sixty Iranian patients with MS ...
We found that, in addition to DR15, DR17 is positively associated with susceptibility to MS; that none of the HLA‐DRB1 alleles influences course or outcome in MS; that carriers of DR15 are prone to MS development at an earlier age than noncarriers; and that differences in DR15 ...
regulationsuppressionHumanized double transgenic mice express both HLA-DR15 (the MHC gene linked to MS) and TCR.Ob1A12 from a multiple sclerosis patient (that recognizes MBP85-99 presented by HLA-DR15), yet they fail to develop autoimmune encephalomyelitis quickly, although 5-10% develop disease...
Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients ( Additional members of the Italian Group for MS Genetics and the Portuguese Group for MS Genetics are listed in the Appendix on page 122.)Mehdi AlizadehMarie-Claude Babron...