发明人: 科斯坦提努斯(科斯塔斯)・科斯马托普洛斯,让娜・梅内-雅梅 摘要: 本发明提供了基于代表肿瘤抗原共有表位的肽有效治疗具有HLA-B*0702表型的患者的新方法和物质.特别地,本发明涉及鉴定可引发针对来自单个多基因家族的数种抗原的细胞毒性应答的HLA-B*0702限制性肽的方法,并涉及数种这样的表位.收藏...
Tetramer/BV421 – HLA-B*0702 CMV (TPRVTGGGAM)推荐供应商 我要询价 MEDICAL & BIOLOGICAL LABORATORIES CO., LTD 联系电话:81366846860 电子邮件:office@bmgrp.at CB指数:58 网址:www.mblbio.com 相关信息:产品目录(12066)用户评价 英文名称:Tetramer/BV421 – HLA-B*0702 CMV (TPRVTGGGAM) ...
In this work, we compared in B*2705/B*07 positive patients with AS, the CD8+ T cell responses to two immunodominant EBV-derived epitopes restricted for either the HLA-B*27 (pEBNA3C) or the HLA-B*07 (pEBNA3A). We have unexpectedly found that the HLA-B*07-restricted EBNA3A peptide ...
HLA-B*27 is strongly associated with an inflammatory autoimmune disorder, the Ankylosing Spondylitis (AS) and plays a protective role in viral infections. The two aspects might be linked. In this work, we compared in B*2705/B*07 positive patients with AS, the CD8+ T cell responses to two...
We examine the effect of mutations in the HLA-B∗0702 α1 domain on the binding of several well-characterized monoclonal antibodies. BB7.1 recognizes the α-helix, with a special requirement for residue 67. Combined with an established requirement for the α2α-helix, BB7.1 appears to span...
Preformed antibodies against HLA-A,B,C molecules cause hyperacute rejection of transplanted allogeneic tissues. To understand better the molecular basis of hyperacute rejection, narrowly reactive anti-HLA-B∗0702 monoclonal antibodies have been studied. Previous epitope mapping studies of these monoclonal...
We examine the effect of mutations in the HLA-B∗0702 α1 domain on the binding of several well-characterized monoclonal antibodies. BB7.1 recognizes the α-helix, with a special requirement for residue 67. Combined with an established requirement for the α2α-helix, BB7.1 appears to span...