HLA-A02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronavirusesKeywordsT cellsSARS-CoV-2antigenspecificCD8TCRsingle-cellCOVID-19immune responsecell therapyNesterenko etal. identify Tcell responses with potential to confer long-term immunity...
Understanding CD8+ T-cell responses toward the native and alternate HLA-A02:01-restricted WT1 epitopedoi:10.1038/CTI.2017.4The Wilms' tumor 1 (WT1) antigen is expressed in solid and hematological malignancies, but not healthy tissues, making it a promising target for cancer immunotherapies. ...
Methods HLA derived peptides predicted to be capable of being bound by HLA-A02:01 were defined using the SYFPEITHI database and commercially synthesised. A TAP deficient,HLA-A02:01 positive cell line (T2) was utilised in assessment of peptide binding via measurement of surface expression of HLA...
We aimed to reveal a unique amino acid sequence (AA) of complementarity‐determining region 3 (CDR3) of the T‐cell receptor (TCR)β and TCRα chains of HLA‐A*02:01‐restricted Tax11–19‐specific cytotoxic T cells (Tax‐CTLs). The gene expression profiles (GEP) of Tax‐CTLs were ...
van den, HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV + Hodgkin lymphoma, Blood 110 (2007) 3310-3315.Niens M, Jarrett RF, Hepkema B, et al.-- HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk ...
The presentation of SARS-CoV-2 peptides by the common HLA-A02:01 molecule - ScienceDirectCD8+ T cells are crucial for anti-viral immunity, however, understanding T cell responses requires the identification of viral epitopes, and their presentation...