在腹部播散性肿瘤模型中,各实验组均未出现肝肾功能异常改变,证实了pHLA-NP和TCR-T细胞治疗的体内安全性。 Neoantigen T-cell receptor gene therapy in pancreatic cancer. N Engl J Med. 2022; 386: 2112-2119. Targeting negative surface charges of cancer cells by multifunctional nanoprobes. Theranostics. 2...
HLA-A0201 positive pancreatic cell lines: new findings and discrepancies. Cancer Immunol Immunother. May; 2007 56(5):719-24. [PubMed: 16947023]Zhu K, Lizee G, Cano P, Fernando-Vina M, Ji B, Abbruzzese JL, et al. HLA-A0201 positive pancreatic cell lines: new findings and discrepancies...
Leidner, R. et al. Neoantigen T-cell receptor gene therapy in pancreatic cancer. N. Engl. J. Med. 386, 2112–2119 (2022). Choi, J. et al. Systematic discovery and validation of T cell targets directed against oncogenic KRAS mutations. Cell Rep. Methods 1, 100084 (2021)....
In conclusion, the multifactorial pathogenesis of pancreatic cancer must always be considered and human leukocyte antigens may show useful predictive and diagnostic value in the near future. Key words: HLA, pulmonary metastases, pancreatic cancer, genetic markers....
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Loss of HLA-A,B,C and de novo expression of HLA-D in colorectal cancer. PMID: 2417962 Interferon-gamma induces the expression of HLA-A,B,C but not HLA-DR on human pancreatic beta-cells. PMID: 3084532 Transcriptional control of HLA-A,B,C antigen in human placental cytotrophoblast isolated...