In the next stage researchers are capable of matching 3 alleles (unknown as the HLA-A) but not the B except through linkage with A. Occasionally A recombined with another B and resulted in a B allele mismatch. Haplotype 1 Haplotype 2 A Cw B A Cw B Donor 1 7 8 2 7 7 Recipient...
Recipient-donor HLA mismatch has a variable but deleterious effect onallograftsurvival.12,13The recognition of non-self HLA molecules by the recipient's T cells is important in triggering rejection processes.12Matching for HLA inheart transplantation, however, is not considered in current allocation ...
Registry reports have shown that the negative impact of allelic mismatch was similar to that of an antigen level mismatch (Lee et al., 2007; Flomenberg et al.; 2004; Shaw et al., 2007) A single allele mismatch at HLA-A, -B, -C, or -DRB1 was associated with higher mortality and ...