进行注释后,在健康、 轻度 COVID-19 和重度 COVID-19 患者中包括11种免疫细胞类型:CD14+ 经典和中间单核细胞、CD16+ 细胞、树突状细胞 (DC)、CD4 和 CD8 T 细胞、NK 细胞、B 细胞、血小板、红细胞(图 4a 和 b)。 比较不同免疫细胞亚群中轻度和重度病例的 MCEMP1 和 HLA-DRA 表达,发现 MCEMP1 的...
一、HLA抗原 人类白细胞膜上的抗原分为三类:一类是红细胞血型抗原,如 ABH、Rh等;另一类是白细胞本身特有的抗原,如CD4、CD8、Leu8等;第三类是与其他组织共有的,也是最强的同种抗原,即人类白细胞抗原(HLA)。HLA又可称为移植抗原、组织相容性抗原或组织抗原(tissue antigen)。早在20世纪60...
通过羧基荧光素琥珀酰酯检测法,作者发现手术后 72 小时从中耳炎小鼠体内分离的单核细胞体外促进 CD4+ T 细胞增殖的能力显著下降,而 S100a9 缺陷可部分逆转这种情况(图 5a)。同样,与假小鼠的单核细胞相比,从 WT 脓毒症小鼠身上收集的单核细胞显示出更强的驱动向 Tregs 分化倾向的能力,而从 CLP 小鼠身上获得的...
HLA class II genes are highly polymorphic, but HLA-DRA gene polymorphisms are highly conserved and are more likely to cause functional changes than other MHC class II genes [28] and have been considered a target of immune-mediated diseases [29]. The relationship between HLA-DRA gene polymorphis...
有报道显示5’UTR和3’UTR在HLA-DRA转录后水平的基因表达调控中发挥着重要作用,控制着mRNA的稳定性和降解速率,决定翻译速率和利用效率,而且还能对特定mRNA的时空性表达起重要作用。目前关于DP基因的表达调控研究较少,有限的资料表明,HLA-DPB1分子的表达调控不同于其他II类分子,类成淋巴细胞系45.EM2正常表达HLA-DQ...
HLA-A、HLA-B、HLA-C II类 HLA-DRA、HLA-DRB1、HLA-DRB3、HLA-DRB4、HLA-DRB5、HLA-DPA1、HLA...
HLA-DR participate in the antigen presentation to CD4+ or CD8+ T cells and is postulated as a general biomarker of sepsis-induced immunosuppression (PMID: 28199206, 32421903). The Anti-Human HLA-DR antibody, clone L243, is derived from Human lymphoblastoid B-cell line RPMI 8866. 实验方案 ...
Class II human leucocyte antigen (HLA) proteins are involved in the immune response by presenting pathogen-derived peptides to CD4(+)T lymphocytes. At the molecular level, they are constituted by alpha/beta-heterodimers on the surface of professional antigen-presenting cells. Here, we report that...
of fluctuation. This is due to a large size of HLA-DR molecules composing two major domains, which are an antigenic binding cleft and the cleft-distal domain interacting with a CD4+ T-cell receptor. Structural flexibilities result from peptide flanking regions and cleft-distal domain while the ...
(human leukocyte antigen,HLA)系统是人类基因组中最具多态性的,因其抗原呈递和调节功能而居于免疫系统的核心位置,与感染性疾病的发生和转归等密切相关.HLA-Ⅱ类分子包括经典的HLA-DR,DP和DQ及非经典的DM和DO,其中HLA-DR等位基因已超过3800个,应是超多态.HLA-DR基因座位包含1个DRA基因和多个DRB基因,其中DRA基因...