Five Bw4 and five Bw6 sera were provided in the serum set Their reaction patterns were highly concordant with at least four positive sera in 72% of the Bw4 cells and 76% of the Bw6 cells. Extra reactions ranged from 3% to 6% for the Bw4 sera and from 1% to 5% for the Bw6 ...
Gene cloning and sequencing of theHLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or-Bw6 to the α-helical region of the α 1 domain flanked by the amino acid positions 74–83. Comparison of...
在此急性期队列中,前期研究发现宿主的HLA遗传背景可以影响病毒调定点的水平,尤其是HLA-B抗原分子中携带Bw4纯合子的急性HIV-1感染者的病毒调定点,显著低于携带Bw6纯合子的感染者,且3年内CD4细胞计数下降至350个/μL以下的患者比例低。Bw4是KIR3DL1受体识别的配体,而KIR3DL1既表达于NK细胞表面,又表达于CD8 细...
This is of considerable interest since has only been described as a rare subtype underrepresented in the British population and has not been previously found to be associated with AS. B*2708 carries the sequence specifying the Bw6 epitope in contrast to most B27 alleles which carry a Bw4 ...
(2005) Two new cases of familial hairy cell leukemia associated with HLA haplotypes A2, B7, Bw4, Bw6. Leukaemia & Lymphoma, 46, 243-245.Villemagne B,Bay JO,Tournilhac O. Two new cases of familial hairy cell leukemia associated with HLA haplotypes A2,B7,Bw4,Bw6[J].Leukemia and ...
Both polypeptide chains are encoded by genes in the HLA-DP, HLA-DQ, or HLA-DR region of chromosome 6. T cells reactive to class II molecules express CD4 and are often helper cells.II 类 MHC 分子通常仅存在于专业的抗原呈递细胞(B 细胞、巨噬细胞、树突状细胞、朗格汉斯细胞)、胸腺上皮细胞和...
HLA简介 北京市红十字血液中心北京红十字血液研究所 谢 谢 A C B Coplement D Centromere 21-OHBC4B21-OHAC4ABfC2 DR DQDQ DNDO DPDP DR A B4 B3 B2 B1 A1B1A2B2A1B1A2B2 HLA分类 1.HLA-ⅠA、B、C 2.HLA-ⅡDR、DQ、DP3.HLA-ⅢBF、C、TNF、HOT、21-羟基酶 HLA结构 HLA-I抗原存在于...
1.4 影响 SPI 检测准确性的因素 1.4.1 抗原数量和质量变异性的影响 :在某个制 造商的 SAB 中,HLA-Cw,HLA-DQ 和 HLA-DP 具有较高的抗原密度,导致这些抗体的风险被高 估[11].相反,一些针对公共抗原表位(如 Bw4 或 Bw6)的抗体有可能被低估,这是由于单个抗体可 能被分散在多个微球上,导致 MFI 水平下降...
DRandDQ associations 宽窄团 强交叉 弱交叉 DR10---DR9DR5 DR11DR12DR8 DR6 DR1---DR4DR13DR14 DR2DR3 DR15DR16DR7DR17DR18 HLA-DRLocus Cross-reactivity HLA-BLOCUSCROSS- REACTIVITY Bw4Bw6 B37B48 B40 B13B60B61B41 B47B73 B27B
Most HLA class I A and B allotypes carry a unique public epitope (Bw4 or Bw6), of which the Bw4 epitope binds to three domain KIR receptors on NK cells. HLA-C, however, possesses either a C1 or C2 epitope that binds to two domain KIR. HLA-B∗46 is one of the few B ...