HLA and disease associations: detecting the strongest association . Tissue Antigens 1994 ; 43 : 18 – 27 .Svejgaard A, Ryder LP. HLA and disease associations: detecting the strongest association. Tissue Antigens. 1994;43:18–27.Svejgaard A, Ryder LP: HLA and disease associations: detecting ...
will be affected with GD can be predicted, based on sex, HLA genotype, and family Comprehensivegenotyping in two homogeneous Graves disease samples reveals major and novel HLAassociation The association of HLA -A, -B, and -DRB1 genotypes with Graves' disease inBM Mahdi...
HLA-A, -B, and -C antigen frequency of 61 Japanese patients with Graves' disease, and HLA-DR and -DQ frequency of 53 patients with it were compared that of 1,998 controls. The prevalence of Bw46 was significantly higher in patients with Graves' disease (23.0% vs 8.4%, Pc less than...
The strongest genetic risk factor of Behet's disease (BD) is. Our group previously reported thatis independently associated with the risk of the onset of BD apart from. Here, we re-evaluated the association betweenand BD in the Japanese population. We also performed a comprehensive literature ...
RESULTS:Sixty-onepercentof31allopurinol-inducedSJS/TENpatientscarriedtheHLA-B*5801alleleandthefigurewas55%for27patientsofEuropeanancestry[oddsratio=80(34187)],(P<10(-6))aspreviouslyobservedinHanChinese.Forotherdrugs,tworareallelesshowedaweakerassociationwithSJS/TENinalimitednumberofpatients:B*38for...
As a result of this updated analysis, HLA supertype associations have been defined for over 750 different HLA-A and -B alleles. This information is expected to facilitate epitope identification and vaccine design studies, as well as investigations into disease association and correlates of immunity....
B44 alleles are highlighted in blue and have significantly lower promiscuity than alleles not belonging to this group (two-sided Wilcoxon’s rank-sum test P: 0.049). c-e, No significant association between HLA-I genotype Pr and (c) HLA homozygosity, (d) HLA-I evolutionary divergence (HED)...
miR-148b and miR-152, therefore decreasing the mRNA availability by mRNA degradation and translation suppression. The influence of the +3142G allele was demonstrated by a functional study in which HLA-G high-expressing JEG-3 cells were transfected with miR-148a, decreasing soluble HLA-G levels...
Journal2011, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Lennart T. Mars, ... Nathalie Arbour 1.3 MHC class I association with MS As reviewed above, CD8+ T cells recognize specific antigens that are presented by autologous MHC class I molecules (HLA-A, B, and C in...
in a dose which varies according to, inter alia, the manner of administration, the peptide being delivered, and the stage of the disease being treated. For solid compositions, conventional nontoxic solid carriers may be used which include, for example, pharmaceutical grades of mannitol, lactose,...