单纯的银屑病患者HLA-B27的发生率没有增高,但45%银屑病性脊柱炎患者可检出HLA-B27抗原。急性葡萄膜炎(AAU),也可以是脊柱关节炎(SpA)的特征表现之一,与HLA-B27的阳性有密切关联。 研究已证实,强直性脊柱炎(AS)的发病和人类白细胞抗原(HLA)-B27有强烈相关性,并有明显家族聚集倾向。在健康人群中,HLA-B27抗原表达...
HLA-B27 and ankylosing spondylitis geographic distribution versus malaria endemic: casual or causal liaison?The distinctive feature of the strikingly non-homogeneous geographical distribution of HLA-B271 (fig 1A) is that its frequency is lowest (0%) in the equatorial region and highest (40%) in ...
Ankylosing SpondylitisSPECT ScanHLA-B27A 35-year-old man, with positive HBV and HCV markers, showed clinical and histopathological features of polyarteritis nodosa (PAN), in the course of HLA-B27 positive ankylosing spondylitis (AS). The possible occurrence of both diseases in genetically ...
过去认为,HLA-B27分子与多肽(多为第2位为精氨酸的9肽)结合形成的复合物被CD8+细胞毒T淋巴细胞识别后触发的自身免疫反应是HLA-B27唯一的致病机制。但国外May等[9]发现,只表达转染的人HLA-B27重链,剔除了β2微球蛋白基因的HLA-B27转基因鼠仍可...
[2] Linssen A, Feltkamp TE. B27 positive diseases versus B27 negative diseases[J]. Ann Rheum Dis, 1988, 47(5): 431-439. [3] Khan MA, Kushner I, BraunWE. Comparison of clinical features in HLA-B27 positive and negative patients with ankylosing spondylitis[J]. Arthritis Rheum, 1977, 20...
前面提到不同亚型HLA-B27与疾病的关联也有所不同,研究表明HLA-B27:04与AS的关联性最强,其次是HLA-B27:05,而HLA-B27:06、HLA-B27:09被认为是保护性基因,马来西亚人AS的发病率很低可能就与HLA-B27:06的保护作用相关[2],HLA-B27:05亚型AS患者伴发葡萄膜炎比例显著高于HLA-B27:04亚型AS患者[7]。
The risk of developing ankylosing spondylitis in HLA-B27 positive individuals The present study was performed on 61 HLA-B27 positive first-degree relatives and 40 HLA-B27 negative relatives of 20 HLA-B27 positive probands with ankylo... SMDV Linden,HA Valkenburg,BMD Jongh,... - 《Arthritis &...
Remarkable Polymorphism of HLA-B27: An Ongoing Saga. Curr Rheumatol Report. 2010; 12: 337-41. - Khan MA. Ankylosing spondylitis and related spondyloarthropathies: The dramatic advances in the last decade. Rheumatol. 2011;50:637-9. - Khan MA. HLA and spondyloarthropathies. In Mehra N (...
带您了解HLA-B27与强直性脊柱炎 临床上经常会遇到这样的患者,年轻男性,腰背部疼痛,易误认为工作劳累导致的“腰肌劳损”。尤其是晚上,翻身都疼,身体有僵硬感,早上起床活动会儿,感觉僵硬有所减轻。此时,应警惕强直性脊柱炎( ankylosing spondylitis,AS)的发生,建议该人群进行人类白细胞抗原B27( human leucocyte ...
二、HLA-B27与脊柱关节病(SpAs)的流行病学 大量的临床研究证实SpAs患者的HLA-B27阳性率明显增高,但此类疾病的HLA-B27携带率并不完全相同,约90~95%以上的AS患者为HLA-B27阳性,约60~80%的ReA、50%伴脊柱关节受累的PsA或IBD相关的关节炎,以及80%的JSpA患者的HLA-B27呈阳性[2]。在临床工作中发现HLA-B27呈阳性...