在SIJ MRI未发现炎症的患者中,可能存在结构性损害、硬化、糜烂和fJSW。然而,fJSW与SIJ MRI所见的炎症严重程度显著相关,有助于nr-axSpA的准确诊断,可作为普通人群中nr-axSpA的替代诊断试验,特别是对于未携带HLA-B27基因且无BME的亚洲...
Background The prevalence of HLA-B27 gene positivity in healthy Caucasian communities varies between 8 and 14%. However, there is a lack of information in countries with a high rate of miscegenation, such as Brazil. Aim To estimate the frequency of HLA-B27 in the Brazilian general population ...
中国人群研究同样观察到12,13,HLA-B27阳性AS患者发病早、全身症状多、合并症多、预后较差,AS患者一级亲属HLA-B27阳性率及AS确诊率均远高于总体人群。 上述研究结果提示,检测HLA-B27有助于预测AS预后,同时对于AS的预防也具有一定意义,例如HLA-B27阳性...
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However, screening of the general population is not recommended, as a positive result merely indicates genetic susceptibility. Accordingly, only a minority of HLA-B27 carriers will develop a disease of the SpA spectrum. Generally, testing for HLA-B27 should not be repeated, although in case of ...
Additionally, the duration of methotrexate use in the HLA-B27 positive group was statistically significantly longer, with a median duration (IQR) of 1.7 (1.1–3.1) years (p = 0.04). The general treatment details and comparison between both groups are summarized in Table 2. Table 2 ...
目的:探讨 HLA‐B27和HS‐CRP的表达与强直性脊柱炎(AS)相关性,以及AS的临床诊断符合率.方法采用双色流式细胞术检测505例关节疾病患者(观察组)以及80例健康人群(对照组),同时检测超敏C反应蛋白(HS‐CRP),抗链球菌溶血素O抗体(ASO)以及类风湿因子(RF).结果505例关节疾病患者中64例为AS(12.67%),116例为疑似AS...
There are three general groups, HLA-A, HLA-B, and HLA-DR. Each group contains many different proteins. HLA-B27 is an allele (one of two or more genes for an inheritable trait that occupy the same location on each chromosome, paternal and maternal) of the HLA-B locus. There are a ...
be found between homozygotic and heterozygotic carriers of this haplotype and patients with other haplotypes. An increased prevalence was also found for the HLA-A9 antigen. The haplotypes A9B7 and A9B27 were significantly more common among the patients investigated than among the general population....
Prevalence of HLA-B27 in the general population and in patients with axial spondyloarthritis in Saudi Arabia HLA-B27 was positive in 82/3332 (2.5%) and 27/1164 (2.3%) individuals in the cord blood and healthy organ transplant donor databases, respectively. ... MA Omair,FK Alduraibi,MK Bed...