2014年5月,在线发表在《Pharmacogenomics》的一项荟萃分析表明,HLA-B* 57:01检测预测阿巴卡韦高敏反应具有较高的诊断准确度,潜在HLA-B *57:01检测可显著降低阿巴卡韦诱导高敏反应的发生率。 目的:通过荟萃分析已发表的研究来确定HLA-B *57预测阿巴卡韦高敏反应的诊断准确率及量化预处理筛选的临床受益。 方法:研...
HLA-B*57:01 Reference StandardEnquiry Product Description Product database Introduction FormatGenomic DNA DescriptionAbacavir is a drug used to treat AIDS, but it has serious adverse reactions and can even cause death. Several studies have shown that patients with the HLA-B*5701 gene are more...
在处方前,对患者HLA-B*5701基因分型可降低这种超敏反应。目前,FDA关于阿巴卡韦药物标签黑框警告中建议在使用阿巴卡韦前,对患者进行 HLA-B*5701基因检测,以减少超敏反应的发生风险。 Technical Data Allele 1 HLA-B*57:01 Allele 2 HLA-B*57:01 Buffer Tris-EDTA Sanger HLA-B*57:01 57:01 Sanger ...
例如,HLA-B* 15:02可以使服用卡马西平(Carbamazepine, CBZ)的中国汉族人群产生史蒂文斯-约翰逊综合症/中毒性表皮坏死松解症(Stevens-Johnson syndrome/toxic epidermal necrolysis, SJS/TEN)的风险增加高达2,505倍;HLA-B*57:01可以使服用阿巴卡韦(Abacavir, ABC)的高加索人群产生超敏反应综合症(Hypersensitivity ...
目的本研究将解析PM-IDILI易感基因HLA-B*35:01中作为何首乌免疫特异质肝损伤易感基因的结构特征,并结合前期发现的何首乌可诱导生成蛋白加合物现象,系统探讨PM-IDILI发生的分子机制,并揭示PM-IDILI发生的分子机制。 方法通过比对HLA-B*...
Real-Time PCR methods to typing HLA-B*57:01 Key words: HIV, antiretroviral therapy, immunogenetics Corresponding author Ombretta Turriziani Department of Molecular Medicine, Sapienza University, V.le dell’Università 31, 00185 Rome, Italy E-mail: ombretta.turriziani @uniroma1.it Page 1 of 22 ...
英文别名: Biotinylated Monomer – HLA-B*57:01 HIV gag (147-155) (ISPRTLNAW) (formerly code #MR01091A) 中文名: 中文别名: CBNumber: CB115380574 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 Biotinylated Monomer – HLA-B*57:01 HIV gag (147-155) (IS...
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procedures to screen the DrugBank database and identify potentially HLA-B*57:01 liable drugs. Then, we compared our workflow’s performance with another model recently developed by Metushi et al., which proposed seven in silico HLA-B*57:01 actives, but were later found to be experimentally ...
Herein, we present a structure-based analysis of the common HLA-B*57:01 variant known to be responsible for several HLA-linked adverse effects such as the abacavir hypersensitivity syndrome. First, we analyzed three X-ray crystal structures involving the HLA-B*57:01 protein variant, the anti-...