9 50 CHINA TROPICAL MEDICIN E Vol.4 No.6 December 2004 中国热带医学 2004 年 12 月第 4 卷第 6 期表 1 海南地区汉 族人群主要的 HLA -A ,B 抗原频率和基因频率分布 Table 1 HLA -A , B frequency and gene f requency distribution in Hainan 阳性数 抗 原频率 基因频率 HLA Positive Antigen...
A marked positive expression was observed for HLA-A, HLA-B/C or B2M in a third of lesions, which is less than seen in cutaneous melanoma (Campoli and Ferrone, 2008). The level of expression of HLA Class I in CoM was not related to the tumour's basal diameter, development of ...
Genetic population data indicate a positive correlation between frequencies of functional SPs in humans and corresponding cytomegalovirus mimics, suggesting a means for viral escape from host responses. The systematic, quantitative approach described herein will facilitate development of prediction algorithms ...
METHODS: We examined the following patients for MICA gene polymorphism by means of polymerase chain reaction and subsequent automated fragment detection by fluorescent-based technology: 64 (37 HLA-B27-positive and 27 HLA-B27-negative) whites with acute anterior uveitis, 74 (67 HLA-B27-negative and...
the predicted binding orientation of the positive analogs can be well accommodated in the pocket with similar binding behavior as abacavir, whereas the negative analogs all presented unfavorable clashes, suggesting disrupted binding or conformation changes within the HLA-B*57:01 peptide-binding groove. ...
Positive control wells received A*02:01, and negative control wells received either HLA A*02:01 or the HLA allele specific to the plate. The resultant peptide exchange reaction mixtures contained 10 µM peptide, 0.1 µM UV–HLA complex and 5% ethylene glycol (v/v). The peptide ...
on positive spots. Since the HLA allele is so numerous, it requires a lot of probes, and each DNA sample is subjected to multiple crosses (or even more than ten times) to finalize the analysis, and the operation is very tedious. On this basis, a ...
(TCR) variants. A few TCR variants that recognize these DQ/antigen complexes are on CD4 positive (CD4+) T-cells. These T-cells, called T-helper cells, can promote the amplification of B-cells which, in turn recognize a different portion of the same antigen. Alternatively, macrophages and ...
ImmuneApp-Neo exhibited a substantially higher positive predictive value (PPV), with a 2.1-fold improvement when compared to all other models, in the identification of immunogenic neoepitopes. Finally, we developed an online platform (https://bioinfo.uth.edu/iapp/) to facilitate multitasking functio...
These peptides would be presented by some, but not all, HLA-B27-positive individuals and could be a source of antigenic diversity of HLA-B27 dependent on the non-B27 HLA class I type of the individual. MATERIALS AND METHODS Synthetic Peptides Synthetic peptides were synthesized using standard...