基因名称: HLA-A 基因又名: HLAA Gene ID: 3105 种属 Homo sapiens 基因序列编号: NM_002116.8 基因描述 Homo sapiens major histocompatibility complex, class I, A (HLA-A), transcript variant 1 (A*03:01:01:01), mRNA DNA编码区: atggccgtcatggcgccccgaaccctcctcctgctactctcgggggccctggccctgacc cagac...
近日，NCI的一篇博客“Cancer Immunotherapies Don’t Work for Everyone: HLA Gene May Explain Why”吸引了读者的注意。文中提到了2021年12月发表在柳叶刀上的一项研究“与具有其他形式的HLA-A基因的人相比，HLA-A*03患者在免疫检查点抑制剂治疗后死亡的更快”1。主要组织相容性复合物(MHC)是一组编码细胞表面蛋...
(beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene ...
The Human leukocyte antigen a (HLA-A) gene PCR Kit 产品及特点: 本产品就是以探针法荧光定量 PCR技术为基础开发的专门检测人类白细胞抗原A(HLA-A)基因的试剂盒,它具有下列特点: 1. 即开即用,用户只需要提供样品 DNA 模板。 2. 引物和探针经过优化,灵敏性高。
该基因编码的蛋白质是一种参与脂质和甘油脂质代谢的线粒体膜蛋白。编码蛋白是一种脂质激酶,催化磷脂酸和溶血磷脂酸的形成这个基因的缺陷与线粒体DNA缺失综合征10有关。[ RefSeq,FEB 2012 ]提供The protein encoded by this gene is a mitochondr 2022-08-08 18:41 News WIKI 相关搜索 AIP...
[5] GONG X, KARCHIN R. Pan-Cancer HLA Gene-Mediated Tumor Immunogenicity and Immune Evasion [J]. Molecular cancer research : MCR, 2022, 20(8): 1272-83. 作者:河豚 审核:胖胖的鹏 排版:Moro MRD技术系列解析(三):背景噪音干扰 如...
[8] NEGRAO M V,LAM V K,REUBEN A,et al. PD-L1 Expression,tumor mutational burden,and cancer gene mutations are stronger predictors of benefit from immune checkpoint blockade than HLA class Ⅰ genotype in non-small cell lung...
HLA的 I 类 A、B、C 位点和 II 类 DR、DQ 位点等位基因的分型检测在造血干细胞移植,骨髓移植以及肝脏肾脏等其他组织器官移植的供体受体配型中发挥关键作用,供受者双方的 HLA基因型匹配程度显著影响移植受体的长期存活率,匹配程度越高,长期存活率越高,HLA 基因型主要是指 HLA-A、B、C、DRB1、DQB1 5个位点。
[8] NEGRAO M V,LAM V K,REUBEN A,et al. PD-L1 Expression,tumor mutational burden,and cancer gene mutations are stronger predictors of benefit from immune checkpoint blockade than HLA class Ⅰ genotype in non-small cell lung cancer[J]. J Thorac Oncol,2019,14(6):1021-1031. DOI:10. 1016...
variants also HL-A ˌā-(ˌ)chel-ˈā 1 : the major histocompatibility complex in humans 2 : a genetic locus, gene, or antigen of the major histocompatibility complex in humans often used attributively HLA antigens HLA typing often used with one or more letters to designate a loc...