因此,以上结果表明:HLA-E:CD94-NKG2A是一个潜在的免疫检查点,介导循环中NK细胞监测中CTCs的逃避。 Figure 3. Functional validations of immune checkpoint HLA-E:CD94-NKG2A in vitro and in vivo 5 RGS18通过AKT-GSK3β-CRE...
These data indicate that the increased secretion of INF-γ by immature CD94/NKG2A+/ CD56bright NK cells generated after haplo-SCT upregulate the cell surface expression of HLA-E on leukemic blasts. Increased HLA-E expression protects leukemic targets from NK-mediated lysis through the inhibitory ...
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C receptors expressed on natural killer and T cell subsets. We show that among 16 common classical HLA class I SP va...
百度试题 结果1 题目载肽后高亲与力结合CD94/NKG2A致NK细胞抑制得分子就是 A. HLA—A B. HLA-B C. HLA-C D. HLA-G E. HLA-E 相关知识点: 试题来源: 解析 E 反馈 收藏
“三打白骨精”形象比喻,学术也会“浪漫” | #癌症免疫疗法 Highlights1,Distinct immune-tumor interactions in circulation, primary, and metastatic lesions2,CTCs escape from NK surveillance by hijacking immune checkpoint HLA-E:CD94-NKG2A3,Blockade of HLA-E:CD94-NKG2A prevents PDAC tumor metastasis vi...
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA class I genes. The unique structure of the HLA-G molecule permi
On transfectants, the tetramer bound to the CD94/NKG2A, CD94/NKGK2B and CD94/NKG2C NK cell receptors, but did not bind to the immunoglobulin family of NK cell receptors (KIR). Surface expression of HLA-E was enough to protect target cells from lysis by CD94/NKG2A+ NK-cell clones....
J E ColiganJ ImmunolJournal of ImmunologyBrooks AG, Borrego F, Posch PE, Patamawenu A, Scorzelli CJ, Ulbrecht M, et al. Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells. J Immunol. 1999;162(1):305-13....
Unexpectedly, the two HLA-E mutations (D69A and H155A) selectively abrogated HLA-E binding to CD94/NKG2A, not largely affected CD94/NKG2C. These results indicate that a mostly shared, but partly distinct set of HLA-E residues is discriminated by the two receptors.doi:10.1002/eji.200324432...
The virtually monomorphic antigen presentation molecule HLA-E can present self- and non-self peptides to the NKG2A/CD94 co-receptor inhibitory complex expressed on natural killer (NK) cells and to T cell receptors (TCRs) expressed on T cells. HLA-E presents self-peptides to NKG2A/CD94 ...