The differentiation protocol alters the ability of HL-60 cells to traverse narrow strictures. (a) Critical cross section where Arrest, Oscillation and Retrotaxis occur in (a) AdHL-60 (ATRA), (b) DdHL-60 (DMSO) and (c) nDdHL-60 (NUTD) in tapered straight channel in chemokine gradients...
Accordingly, gene expression analysis showed the HOXB1-dependent down-regulation of some tumor promoting genes, paralleled by the up-regulation of apoptosis- and differentiation-related genes, thus supporting a tumor suppressor role for HOXB1 in AML. Finally, we indicated HOXB1 promoter ...
Several pieces of evidence suggest that CD38 may be a key driver of all-transretinoic acid (RA)-induced differentiation. In HL-60 acute myeloid leukaemia cells, a model for RA-induced differentiation, RA induces dramatic upregulation of CD38 mRNA and protein expression within 8 h13,14,15,16....