The ATRA-differentiated granulocytic form of HL-60/S4 cells had an enhanced transcriptional response to TNF-α treatment compared to the undifferentiated promyelocytes. The observed TNF-α responses included differential expression of cell cycle gene sets, which were generally up...
Mark Welch DB, Jauch A, Langowski J, Olins AL, Olins DE. Transcriptomes reflect the phenotypes of undifferentiated, granulocyte and macrophage forms of HL-60/S4 cells. Nucleus (Austin, Tex). 2017;8:222-37.Mark Welch DB, Jauch A, Langowski J, et al. Transcriptomes reflect the phenotypes ...
The previous publication [17] also examined the role of MTs on nuclear lobulation in HL-60/S4 cells. They exposed RA treated cells to 0.1 μM (0.03 μg/ml) NC for up to two days, concluding that the integrity of MTs was not important to the formation granulocytic nuclear lobes. We ...
The human leukemia cell line (HL-60) is an alternative to primary neutrophils in research studies. However, because HL-60 cells proliferate in an incompletely differentiated state, they must undergo differentiation before they acquire the functional prop
Methods: Using HL-60 cells as experimental object the experimental research of Chansu(toad cake Venenum Bufonis), the chief component of Liu Shen Wan, was carried out. With trypan blue as the index of activity the cellular apoptosis was observed by means of microscopy and flowcytometry. ...
体拜实验结栗表鹾,艟蟾毒酝蘩对入鸯盘病鹣一60及害颈藏Hela蠹缒生长臻 有显著的抑制作用,诚种作用存在时间依赖关系和剂量依赖关系,Ic50约在lo一 1.001.tmolfL。流式细胞术及琼脂糖凝胶电泳结果显示,脂蟾毒配慧对两者癌细胞的细 戆毒馋攥稳铡与诱导燕麴惹调亡毒关。 体内实验证实,商剂量脂蟾毒配基(15mg/...
The release of S100A8/A9 complex in the cell culturing medium was observed in the HL-60 cells treated with vildagliptin and M20.7. Therefore, the parental vildagliptin- and M20.7-induced release of S100A8/ A9 complex from immune cells, such as neutrophils, might be a contributing factor of ...
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T.cells in the skin lesions of a patient、Ⅳith toxic epidermal 大限度的降低抗癫痫药物的副作用提供了确切的 necrolysis[J].J Invest Dermato,2002,1 18(4):728—733. 理论依据。 【6】Nasisbitt DJ,Britschgi M,Wong G,et ai.Hypersensitivity ...
Meanwhile, the treatment of b-AP15 elevate TRAIL-induced apoptosis in human renal caner Caki cells [59]. The other reports also emphasized the importance of UCHL5 in regulating renal cancer meta- bolic and cell cycle process [60]. These studies were mainly focused on renal cancer cell and ...