然而,HK2完全敲除可致胚胎致死,在肠道中,Hk2主要由肠上皮细胞(IECs)表达,但IECs中选择性敲除HK2是否改变上皮功能尚不清楚。 发表于Cell Metabolism杂志的一篇研究表明:IECs中HK2的缺失通过减少炎症诱导的上皮细胞死亡保护了DSS诱导的小鼠...
虽然已有研究证实代谢产物调节干细胞功能，但对于定位在细胞核中的直接影响基因表达、细胞分化和干细胞功能的线粒体代谢酶知之甚少。近日，来自加拿大玛格丽特公主癌症中心的Aaron D. Schimmer团队在Nature Cell Biology杂志上在线发表了题为The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal...
虽然已有研究证实代谢产物调节干细胞功能,但对于定位在细胞核中的直接影响基因表达、细胞分化和干细胞功能的线粒体代谢酶知之甚少。 近日,来自加拿大玛格丽特公主癌症中心的Aaron D. Schimmer团队在Nature Cell Biology杂志上在线发表了题为The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal...
3. Gut, P. & Verdin, E. The nexus of chromatin regulation and intermediary metabolism.Nature502, 489-498 (2013). 4. Moussaieff, A. et al. Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the earl...
在SCI杂志上发表论文100多篇,包括在国际上具有重要影响力的期刊,如Nature Cell Biology,Molecular Cell, Cell Metabolism, Nature Communications, Science Advances, ,PNAS,和EMBO Journal等.被引用超过10,000次。 第一作者 李明月博士:中国科学技术大学生命科学与医学部博士后,主要研究方向:应激条件下,肿瘤代谢重编程...
The AML group with blasts presenting high PL or high basal OXPHOS plus high SRC levels had shorter overall survival time and significantly overexpressed myeloid cell leukemia 1 (MCL1) protein. We demonstrate that MCL1 directly binds to Hexokinase 2 (HK2) on the outer mitochondrial membrane (OMM)...
3. Gut, P. & Verdin, E. The nexus of chromatin regulation and intermediary metabolism. Nature 502, 489-498 (2013). 4. Moussaieff, A. et al. Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metab. 21, 392-402...
The tumor cell membrane protein programmed cell death ligand 1 (PD-L1, also known as B7-H1) specifically binds to programmed cell death 1 (PD-1) on T cells, thereby forming an immune checkpoint. This binding inhibits the activation, expansion, and effector functions of CD8+ T cells and in...
Material and methods A novel small molecule VDAC/HK2 modulator, VDA-1102, is being developed as a bi-functional drug for the treatment of solid tumours – triggering apoptosis in cancer cells while simultaneously enhancing an immune-mediated anti-tumour response by regulating immune cell metabolism....
Jin, F., Wang, Y., Zhu, Y.et al.The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma.Sci Rep7, 3089 (2017). https://doi.org/10.1038/s41598-017-03407-3 Download citation Received13 February 2017 ...