O'Shea S;Chrystie I;Cranston R;et al.Problems in the interpretation of HIV-1 viral load assays using commercial reagents.,2000O’shea J,,Chrystie I,Cranston R,et al.Problems in the interpreta-tion of HIV-1 viral load assays using commercial reagents.Journal of Medical Virology. 2000...
or “Nonreactive” or “Undetectable”. The most common ones detect HIV-1 virus plus the level of virus in the blood, commonly called an HIV “viral load”. Quantitative HIV-2 NAT is only used in the rare case of suspected or known HIV-2 infection. These ...
After a patient’s viral load is undetectable on ART, patients may have occasional “blips” in which the viral load becomes detectable again for a short time. Although an isolated “blip” is not a sign that treatment is no longer working, some patients experience more significant increases i...
However, given the nature of the data reported from included studies (e.g., a wide range of VL coverage across study settings); these limitations are unlikely to affect the results and their interpretation substantially. Few studies reported a complete viral load cascade (number/proportion of ...
Furthermore, given the challenges of reaching representative samples of key populations, significant attention to meaningful recruitment, decentralization of care and interpretation of results is needed. Finally, improving the interoperability of health systems through judicious use of biometrics or identifiers...
6. Interpretation of HIV test results If any HIV-1/2 antigen-antibody immunoassay test is NONREACTIVE, then the test result should be interpreted as not infected with HIV-1 or HIV-2. If acute HIV is suspected, then there will be a need to perform HIV-1 RNA test. ...
HIV viral load (VL) and resistance mutations pre-ART and after 6 months were determined in a prospective cohort study of ART-naïve HIV patients initiating first-line therapy in Jimma, Ethiopia. VL measurements were done at baseline and after 3 and 6 months. Genotypic HIV drug resistance (...
The prescription of suboptimal therapy in patients with high viral load uniformly led to selection of drug resistance. The benefit of initial antiretroviral regimens was only transient and, therefore, plans for rescue were considered in advance. In this scenario, resistance and cross-resistance became...
we used a simulation approach in which we introduced known numbers of breakpoints in simulated data to estimate strand switching events in vivo. Another caveat in the interpretation of our results is that as the sampling times increases and sequences become more divergent, the chance of a converge...
HIV-1病毒抗药性是抗病毒治疗失败的主要原因。理论上,病毒在治疗存在的情况下体验到的体内适应性景观可以用来确定病毒对治疗的敏感性和抗药性的遗传障碍。我们提出了一种方法,通过反向工程确定治疗前的HIV-1患者所需的选择性压力,使其发展到得到治疗的患者的序列,从而从不同亚型的临床遗传序列数据中估计这种适应性景观...