暴露后预防(PEP),全称Post-Exposure Prophylaxis,是指尚未感染艾滋病病毒(HIV)的人员,在暴露于高感染风险后,如与HIV感染者或感染状态不明者发生体液交换行为,及早(≤72 h)服用特定的抗病毒药物,降低HIV感染风险的方法。 2022年,上海市普陀区疾病预防控制中心对上海...
PCP Prophylaxis in HIV-Infected Renal Allograft RecipientsHahnemann University Hospital
The level of CD4 cell count helps determine when to start preventive (prophylaxis) therapies for these infections. The viral load measures the amount of virus circulating in the blood. The viral load is used to determine the response to drug therapy. The goal of therapy is an “undetectable”...
The level of CD4 cell count helps determine when to start preventive (prophylaxis) therapies for these infections. The viral load measures the amount of virus circulating in the blood. The viral load is used to determine the response to drug therapy. The goal of therapy is an “undetectable”...
对于感染HIV高风险人群,在知情同意以及高依从性前提下提供抗病毒药物来进行相应的暴露前预防(Pre-exposure prophylaxis,PrEP)和暴露后预防(Post-exposure prophylaxis,PEP)。 二、 病原学特征 HIV在病毒分类学上属于反转录病毒科慢病毒属中的人类慢病毒组,为直径 100~120 nm的球形颗粒,由核心和包膜两部分组成。
他们事后都没有就医,患者也没有考虑进行HIV的暴露后预防(post-exposure prophylaxis, PEP),在这个年代,他很可能对PEP一无所知。 患者的亲弟弟在搏斗发生时正在接受高效抗逆转录病毒治疗(highly active antiretroviral therapy, HAART),方案为齐多夫定-拉米夫定合剂+奈韦拉平(AZT+3TC+NVP)。但弟弟的血浆病毒载量可检...
1976年,Delanoe提议将其改为耶氏肺孢子菌(Pneumocystis jirovecii,PJ),以纪念捷克寄生虫学家耶诺维奇(Jirovecii)。1988年,Edman发现其核糖体RNA与真菌类似,提出分子水平PJ属于真菌。2001年,在机会性原生生物国际研讨会上,正式将PJP代替PCP,之后文献越来越多采用PJP。
[10] Messiaen P E, Cuyx S, Dejagere T, et al. The role of CD4 cell count as discriminatory measure to guide chemoprophylaxis against Pneumocystis jirovecii pneumonia in human immunodeficiency virus-negative immunocompromised patients: A systematic review[J]. Transpl Infect Dis, 2017 Apr;19(2)...
[10] Messiaen P E, Cuyx S, Dejagere T, et al. The role of CD4 cell count as discriminatory measure to guide chemoprophylaxis against Pneumocystis jirovecii pneumonia in human immunodeficiency virus-negative immunocompromised patients: A systematic review[J]. Transpl Infect Dis, 2017 Apr;19(2)...
PEP:post-exposure prophylaxis,暴露后预防,或者俗称为「阻断」。 EIA:enzyme immunoassay,酶免疫分析,用于抗体或者抗原抗体的测定。 ELISA:enzyme-linked immunosorbent assay,酶联免疫吸附测定,同上。 S/CO:signal to cut-off ratio,吸光度/临界值,是一个比值,用于判定阴阳性。 WB:Western Blot,蛋白质印迹试验,用于...