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resides at the primary cilium and prevents ciliary localization and activation of Smo.Upon Hh binding, however, Ptch is suppressed and displaced from the ciliary membrane.This permits Smo to enter the primary cilium and initiate a cascade of events that lead to the activation of Gli transcription...
Jie LuoHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, ChinaYuan-Bin LiuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, ChinaBao-Liang SongHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, ...