Our analysis shows that successful lead generation requires not only an accurate definition of the needs (to define the most relevant assay protocols and readouts), but most of all a good hit as a starting point. It also appears that teams where techniques and knowledge are combined, are ...
Figure 3. The overall procedure workflow used for the definition of the 3-D pharmacophore/3-D QSAR models and their analysis is depicted as a “black” pathway. The application of generated 3-D pharmacophore/3-D QSAR models in structure-based and ligand-based virtual screening is depicted as...