In 1994, the total synthesis of taxol was a significant step towards producing anticancer drugs, and a gene called obese was cloned. There were also reports of quantum teleportation in 1997 and gravitational lensing— a key test of relativity theory — in 1993, as well as the synthesis of ...
Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding. Science 348, 242–245 (2015). Article CAS PubMed PubMed Central Google Scholar Scott, E. M. et al. Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery. Nat. ...
Such metaphors convey several messages: a definition of the gene as the basis of human destiny, an expectation that genetic research will enable the prediction of future disease, and a promise of therapeutic solutions. These messages are disseminated by a receptive press. ...
We present a phylogeny describing the evolutionary history of the UCP gene family and show that the genes have evolved through duplications followed by purifying selection except for a single site in the mitochondrial matrix between the 5th and 6thα-helices which has undergone positive selection.Back...
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Family history of von Hippel–Lindau disease was uncommon in Chinese patients: suggesting the higher frequency of de novo mutations in VHL gene in these pa... Journal of Human GeneticsWu P, Zhang N, Wang X et al (2012) Family history of von Hippel–Lindau disease was uncommon in Chinese ...
Chromium(VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Mouse MT-I (metallothionein-I) transcription is regulated by MTF-1 (metal-response-element-binding transcription factor-1) which is recruited to the promot... T ...
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et al. Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis. Nat. Commun. 1, 1–7 (2010). Article CAS Google Scholar Elguero, E. et al. Malaria continues to select for sickle cell trait in Central Africa. Proc. Natl Acad. Sci. USA 112,...
Genome doubling has led to an array of molecular genetic interactions, including inter-locus concerted evolution, differential rates of genomic evolution, inter-genomic genetic transfer, and probable alterations in gene expression. The myriad underlying mechanisms are also suggested to have contributed to...