and vaccinations. Some pathogens or vaccines can produce superantigens which are proteins that bind to certain antibody V domains, thus will result in skewed antibody repertoires or even shared antibodies among individuals (Silverman and Goodyear2006). In contrast, public TCRs have MHC restrictions ...
Hundreds of scientists had worked on mRNA vaccines for decades before the coronavirus pandemic brought a breakthrough. By Elie Dolgin Twitter Facebook Email In late 1987, Robert Malone performed a landmark experiment. He mixed strands of messenger RNA with droplets of fat, to create a kind of ...
It was clear, by the fall of 2020, COVID-19 vaccines could reduce symptomatic COVID-19 and also severe disease against prevailing strain(s) in adults. This finding will be remembered as a seminal moment in medical history, and two of these products rapidly received emergency use authorization...
RNA therapy refers to the treatment or prevention of diseases using RNA-based molecules. The recent advent of a series of effective messenger RNA-based vaccines in response to the COVID-19 pandemic has reignited research interest in RNA therapy. Based on
These are the years that Israel became a laboratory of Pfizer and their vaccines. Finally Pluto will oppose the Moon of Israel in 2025,2026,2027 (2). This is a difficult decade for Israel even without considering the general problems the world will face as has been outlines here for months...
the article aims to present the geographical distribution of the early work, how the development of the technology was implemented by several independent and internationally distributed research teams, as well as the controversies on the optimal way to design or formulate and admini...
Vaccines are important preventive measures against severe COVID-19 disease, hospitalization, death, and persistent symptoms (ie, long COVID). The FDA Vaccines and Related Biological Products Advisory Committee (VRBPAC) continues to assess the optimal composition of COVID-19 primary and booster vacc...
The advent of modern antibiotics contributed enormously to the dramatic extension of human lifespan since their discovery by virtue of their lethal and selective action against pathogenic microbes. And yet despite our powerful arsenal of weapons against
A brief history of antibiotics and select advances in their synthesis Kyriacos C Nicolaou and Stephan Rigol The advent of modern antibiotics contributed enormously to the dramatic extension of human lifespan since their discovery by virtue of their lethal and selective action against pathogenic microbes...
Although chimeric antigen receptor (CAR) T cells are effective against B-lineage malignancies, post-CAR relapse is common, and efficacy in other tumors is limited. These challenges may be addressed through rational manipulations to control CAR T cell function. Here we examine the impact of cognate...