Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001). This paper describes the first analyses from the draft human genome sequence assembled over the previous decade: it launched modern human genetics and represents a tribute to the power of collaborative science. ...
HUMAN genesGenetic editing has many applications in almost all areas of society, but may also lead to unpredictable consequences. Genome editing to modify the human germline is at the center of global discussion. Owing to the increasing number of unanswered scientific, ethical, ...
Nearly all genetic variants that influence disease risk have human-specific origins; however, the systems they influence have ancient roots that often trace back to evolutionary events long before the origin of humans. Here, we review how advances in our understanding of the genetic architectures of...
TEs are DNA sequences that can translocate or duplicate themselves within the genome and thus are abundant in human and NHP genomes. There are two major classes of TEs: DNA transposons, which mobilize in the genome through a non-RNA-mediated cut-and-paste mechanism, and retrotransposons, which...
To examine the evolutionary history of Homotherium, we generated a ∼7x nuclear genome and a ∼38x exome from H. latidens using shotgun and target-capture sequencing approaches. Phylogenetic analyses reveal Homotherium as highly divergent (∼22.5 Ma) from living cat species, with no ...
The RNA-guided nucleases from CRISPR-Cas systems are currently regarded as the most reliable tools for genome editing and engineering. The first hint of their existence came in 1987, when an unusual repetitive DNA sequence, which subsequently was defined as a CRISPR, was discovered in the ...
The project was the idea of human rights activist David Keyes.Qualified, an episode of ESPN 30 for 30 covering her racing career, aired on May 28, 2019. In it she is quoted "You can go back to antiquity to find women doing extraordinary things, but their history is forgotten. Or ...
of them is exempt-must change before the coming rush of facts.” The way genetics impacted on plant breeding turned out to depend upon the mating system of the crop species, as might have been anticipated from Darwin’s book of 1876 onThe Effects of Cross and Self Fertilisation in the ...
The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity. Here, we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet. The phylogeny of ...
To date, no complete MPXV viral genome has been published from the human cases identified in the CAR. The objective of this study was to sequence the full genome of 10 MPXV isolates collected during the CAR epidemics between 2001 and 2018 in order to determine their phylogenetic relationships...