This chapter introduces the history of Integrative Bioinformatics. Particularly, it outlines major events in the field from Germany who took a leading role and from China who plays a rapid developing counterpart. The earliest bioinformatics database resources, projects and initiatives are mentioned. We...
and Haghighi,F.G. (... FG Haghighi - 《Bioinformatics》 被引量: 13发表: 2011年 Tale of two cultures: are there database research issues in bioinformatics? It was the best of times, it was the worst of times, it was the age of biology, it was the age of computer science, it ...
Here we map the coevolutionary history of the oldest elementary functional loop prototypes (herein referred to as loops) and protein structural domains defined at the superfamily (SF) level of the SCOP database17 (herein referred to as domains). We reveal Evolutionary Bioinformatics Laboratory, ...
Garlic is an entirely sterile crop with important value as a vegetable, condiment, and medicine. However, the evolutionary history of garlic remains largely unknown. Here we report a comprehensive map of garlic genomic variation, consisting of amazingly
A taxonomic classification that accurately captures evolutionary history is essential for conservation. Genomics provides powerful tools for delimiting species and understanding their evolutionary relationships. This allows for a more accurate and detail
This opens the possibility to study the quantitative details of one’s genealogical history and identify emerging patterns. The patterns of IBD segments in large cohorts and biobanks have been extensively studied. However, the scope of some studies is limited to unveil detailed pedigree information ...
Ancient northern East Asians (ANEA) from the Yellow River region, who pioneered millet cultivation, play a crucial role in understanding the origins of ethnolinguistically diverse populations in modern China and the entire landscape of deep genetic struc
The Neolithic and Bronze Ages were highly transformative periods for the genetic history of Europe but for the Aegean—a region fundamental to Europe’s prehistory—the biological dimensions of cultural transitions have been elucidated only to a limited extent so far. We have analysed newly generated...
J. GARLIC: Genomic Autozygosity Regions Likelihood-based Inference and Classification. Bioinformatics 33, 2059–2062 (2017). Article CAS PubMed PubMed Central Google Scholar Zhuang, Z., Gusev, A., Cho, J. & Pe'er, I. Detecting identity by descent and homozygosity mapping in whole-exome ...
(Fig.3C).Footnote53For a time, it remained unknown whether the three domains were equally separated from one another or alternatively, two of the domains were closer to one another than to the third one. To answer this question, two teams applied paralogous rooting phylogenetic bioinformatics ...