Several new studies are discussed suggesting that low or declining testosterone level could be a risk factor for prostate tumorigenesis. This review emphasizes the need for continued research on Testosterone and 5ARI to further define their role in men's health.Ananias C. Diokno...
A case-controlled study in Italy showed that lower testosterone levels in male COVID-19 patients (n = 286) were associated with a higher risk of ICU admission and death outcomes [74]. Subsequently, a single-center cohort study showed that lower testosterone levels during hospitalization were...
is exposed to elevated levels of androgens. Researchers have found that girls with CAH tend to be masculinized in some aspects of their preferences and behaviors (e.g., Berenbaum and Snyder1995). Studies of prenatal exposure to normal variations in hormones such as testosterone (Cohen-Bendahan ...
High levels of steroids are associated with male puberty and heavier muscular growth in boys. In addition to changing the boy’s body, steroid also affects men’s emotions and thoughts. For example, without testosterone hormone, a man would not grow facial hair due to it being a product of...
CYP3A4 is the most abundant of the human P450 enzymes and metabolizes multiple struc- tural classes of drugs (e.g. cyclosporine, quini- dine, testosterone, nifedipine, etc) [77, 78]. CYP3A4 is a focal point of many drug– drug interactions and dietary and herbal interactions. CYP3A4 ...
Several new studies are discussed suggesting that low or declining testosterone level could be a risk factor for prostate tumorigenesis. This review emphasizes the need for continued research on Testosterone and 5ARI to further define their role in men's health.Ananias C. Diokno...
TestosteroneProstate CancerRisksA long-standing belief is that higher testosterone (T) will increase the risk of prostate cancer (PCa), yet recent studies do not support this view. To identify the key historical and scientific events leading to the establishment and persistence of the belief in a...
MENIMPOTENCETESTOSTERONESCREENINGTESTSThe heart is strategically positioned to function as a sensor of central circulatory hypervolaemia and, of course, its own dysfunction. One mechanism by which the heart can respond to such distress or overload was discovered in the early 1980s involving release ...
Soon several groups had isolated and characterized androgenic hormones, first androsterone, then androstendione and finally testosterone [47, 48], which was crystallized in 1935 [49]. Kochakian [50] has given a detailed review of the early investigations on androgens. For almost 40 years it was...