Lactylation is a newly discovered epigenetic modification. 中文翻译: 组蛋白乳酸化将代谢和基因调控联系起来 细胞部分通过组蛋白的化学标记来调节基因表达。来自乳酸分子的标记的发现揭示了细胞将基因表达与营养代谢联系起来的方式。乳酸化是一种新发现的表观遗传修饰。
In Nature, Zhao and colleagues show that lactate drives the lactylation of histone lysine residues and directly modulates gene transcription. In human HeLa cells and mouse bone marrow–derived macrophages (BMDMs), histone lysine lactylation (Kla) is driven by extracellular lactate or glucose-...
Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the gl...
These results reveal a histone lactylation-driven mechanism inducing ferroptosis through METTL3-mediated m6A modification. Targeting METTL3 represents a promising therapeutic strategy for patients with sepsis-associated ALI.关键词 FerroptosisHistone lactylationN6- methyladenosineSepsis-associated acute lung ...
allowing lactate to access intracellular signaling pathways such as the STAT3, Akt and AMPK pathways to control energy balance8. Nonetheless, the mechanism of lactate regulation of energy metabolism is still only the tip of the iceberg. Recently, lactate-derived lysine residue lactylation (Kla) was...
Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, the role of histone lactylation in tumorigenesis remains unclear. Results Here, we show histone lactylation is eleva...
Two model systems strengthen the claim that metabolism alters histone lactylation Hypoxia and the polarization of macrophages to an M1 phenotype both reprogram cell metabolism towards glycolysis, thereby increasing lactate production and histone lactylation ...
The process of lactate metabolism and histone lactylation. For ATP generation, glucose can be processed in both OXPHOS and glycolysis. Firstly, glucose is transported into cells by glucose transporters (GLUTs) and metabolized into Glucose-6-Phosphate via hexokinase. After a serious of enzymatic reac...
Clinical, Cosmetic and Investigational Dermatology Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Histone Lactylation Participates in Psoriasis Progression by Regulating the Adiponectin Expression Sicheng Zhao, Tingyan Wu, Mingjing Fu, Zhe Zhang ...