乳酸化（Lactylation）：Histone H3乳酸化主要发生在赖氨酸上，不同位点的乳酸化修饰也有不同的功能影响。H3K18la（HistoneH3 的第18位赖氨酸残基上发生的乳酸化修饰）在多种疾病中起作用：在败血症引起的肺损伤中，通过m6A修饰ACSL4促进铁死亡；H3K18la也被作为感染性休克的潜在生物标志物进行研究。H3K9la（Histone ...
Lactate can induce histone lysine lactylation (Kla, a recently identified histone marks) to regulate transcription. However, the functional consequence of histone Kla under hypoxia in ESCC remains to be explored. Here, we reveal that hypoxia facilitates histone H3K9la to enhance LAMC2 transcription ...
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored. Here, we report that HBO1 functions as a lysin
Histone lactylation is regulated by diverse enzymes known as writers, erasers and readers, responsible for addition, removal, recognition and interpretation of histone lactylation, respectively (Fig.1). Zhang et al. first showed p53-dependent p300-mediated H3 and H4 lactylation in macrophages, su...
Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, the role of histone lactylation in tumorigenesis remains unclear. Here, we show
Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion Article Open access 26 December 2024 Celastrol assuages oxygen-glucose deprivation and reoxygenation-induced damage in human brain microvascular endothelial cells through the circDLGAP4/miR-6085/GDF11...
Metabolic regulation of gene expression by histone lactylation. Nature 574, 575–580 (2019). This article reveals the widespread occurrence of a new histone PTM. Article CAS PubMed PubMed Central Google Scholar Farrelly, L. A. et al. Histone serotonylation is a permissive modification that ...
sensitivity mass spectrometry and biochemical analyses, in addition to traditional lysine acetylation, methylation, and phosphorylation [39], a variety of novel acylation modifications derived from cellular metabolic intermediates have been discovered, such as succinylation, crotonylation, and lactylation [40...
Moreover, the developmental rate of in vitro cultured embryo was significantly reduced by low oxygen concentration and small molecule inhibition of LDHA activity led to decreased lactate production, as well as reduced histone lactylation and compromised developmental rate. Conclusions We provided for ...
Mechanistically, DML opposed the progress of hepatocellular carcinoma (HCC), which was efficiently facilitated by the increase in H3 histone lactylation. Two histone modification sites: H3K9la and H3K56la, which were found to promote tumorigenesis, were inhibited by DML. In addition, we used a ...