We demonstrate that LHPP is indeed a protein histidine phosphatase. Consistent with these observations, global histidine phosphorylation was significantly upregulated in the liver tumours. Sustained, hepatic expression of LHPP in the hepatocellular carcinoma mouse model reduced tumour burden and prevented ...
Immunoblotting is a ubiquitous immunological technique that aids in detecting and quantifying proteins (including those of lower abundance) and their posttranslational modifications such as phosphorylation, acetylation, ubiquitylation, and sumoylation. T
The histidine protein kinase (HPK), a secondary thermoreceptor, is a two-component phosphoric acid system that consists of a sensor signal input and an echo regulator protein (RR) that controls the signal output. From: Environmental and Experimental Botany, 2023 ...
In eukaryotic cells, protein-bound phosphohistidine constitutes a significant amount of the total phospho- amino acid (5). Still, only a very low number of phosphohistidine-containing proteins have been identi- fied in contrast to the great number of proteins phos- phorylat...
The precursor to histamine is histidine, which is a semi-essential amino acid. It is considered semi-essential because while adults make enough of it, children need to get a sufficient amount from their diet from high-protein foods such as meat. In the brain, histidine is converted to histam...
PHPT1 Antibody is a Rabbit Polyclonal antibody against PHPT1. PHPT1 (Phosphohistidine phosphatase 1), also known as 14 kDa phosphohistidine phosphatase, is a 125 amino acid enzyme belonging to the Janus protein family. Existing as a monomer in the cytopl
The phytase subfamily of histidine acid phosphatases: Isolation of genes for two novel phytases from fungi Aspergillus terreus and Myceliophthora thermophila - Mitchell, Vogel, et al. - 1997 () Citation Context ...mily [6]. So, based on the protein sequence similarity, the studied proteins ...
strain PCC 6803 influences sensitivity to chemically different growth inhibitors and has amino acid similarity to histidine protein kinases. Microbiology, 141, 2915–2920 (1995) PubMed CAS Google Scholar Kaneko, T.; Sato, S.; Kotani, H.; et al. Sequence analysis of the genome of the ...
Introduction PHPT1 is a member of the Janus protein familyand is 125 amino acid long. PHPT1 appears as a monomer in the cytoplasm and is an EDTA-insensitive phosphohistidine phosphatase. Overexpression of PHPT1 resolts in specific phosphohistidine phosphatase activity towards phosphopeptide I, with...
a His/Tyr phosphatase in the PGAM family that negatively regulates bone differentiation and controls platelet glycoprotein VI signaling.113,114 Bearing this in mind, it would be worth investigating the use of standard pSer/pThr and pTyr phosphatase inhibitors, like okadaic acid and orthovanadate, re...