Histamine plays a major role in inflammation associated with many different diseases, including allergies, autoimmune diseases and cancer, but it also has important physiological effects. Although mast cells and basophils are the main sources of histamine it can be differentially produced and released ...
We examined the possible involvement of mast cells in a rat model of colitis, by monitoring levels of histamine at various times after inducing inflammation with intrarectal trinitrobenzene sulfonic acid in 50% ethanol. The ability of a histamine H1 antagonist, diphenhydramine, to modify colitis was...
The local concentration of histamine at sites of inflammation and immune responses is invariably high. Recent studies suggest that the biological relevance of this accumulation of histamine extends beyond its well-characterized role in mediating allergic reactions. In this article, András Falus and Kathe...
Role of prostaglandin-mediated vasodilatation in inflammation INFLAMMATORY reactions are characterised by hyperaemia and exudation of plasma resulting in tissue swelling. Putative mediators of inflammation have usuall... TJ Williams,MJ Peck - 《Nature》 被引量: 901发表: 1977年 Responses of skin blood...
The study, which appeared in The Journal of Neuroscience, reveals that inflammation-induced histamine might also contribute to depression.Lead author Dr. Parastoo Hashemi, from Imperial’s Department of Bioengineering, said: “Inflammation could play a huge role in depression, and there is already ...
whereas H2R blockade reduces CCL24 production from wild-type cells. In an allergic inflammation model, H2R knockout mice show significantly reduced eosinophilic inflammation and CCL24 expression. These data demonstrate a previously unidentified role for H2R in allergic inflammation and establishes a syn...
increased in the mucosa of patients with active IBD, but the underlying immune mechanism to drive inflammation via histamine receptors is not well defined.28 Previous studies in humans have failed to identify a clear role for either H1R or H2R,28 despite both being found on cells in the gut...
inflammation (notably allergic inflammation such as hay fever). Other clinical uses of subtype antagonists may be found inChapters 27,28and40. The pharmacology of H4receptors is less well developed but strongly suggests that the receptor has a significant role in the inflammatory response. ...
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Here, we review accumulating evidence suggesting that histamine indeed has roles in inflammation and immune function modulation in such diseases. In particular... RL Thurmond,EW Gelfand,PJ Dunford ...
Histamine’s role in allergic reactions was first discovered in 1932, and we now know it plays a central role in autoimmune conditions, inflammation and inflammatory disease (Patel et al. 2022). It has both pro- and anti-inflammatory effects, depending on which receptor is activated and in wh...