the U-shaped dentate gyrus and surrounding CA. Second, the segment of dentate gyrus visible from within the ventricle and along its medial surface is known by 3 terms depending on location: the band of Giacomini in the head/uncus, margo denticulatus in the body, andfasciolacinerea in the ...
Brain function depends on inhibitory cells that balance or 'brake' excitation. These neurons allow the brain to process information and also prevent runaway seizures. A new study from the George Washington University (GW), however, reports that in some critical structures of the developing brain, ...
Eight dots (four purple and four white) were always presented on the screen in each trial. The spatial configurations of these dots were manipulated experimentally to produce different levels of uncertainty—for example, when the purple dots were spaced widely apart, the location of the hidden ...
The extent of external and internal factors contributing to location-specific firing of hippocampal place cells is currently unclear. We investigated the role of active movement in location-specific firing by comparing spatial firing patterns of hippocampal neurons, while rats either ran freely or rode...
However, these studies suffer from the complementary problem to the one above: it is unclear whether the location codes observed in these regions are general spatial codes, or specific to landmark objects. To disentangle these issues, here we examined how the human brain learns to encode objects...
a, Coronal brain section showing location of cannula in the dorsal hippocampus (black arrow) together with position of guide cannula in overlying cortex. b, Coronal brain section showing spread of muscimol (red) after infusion into the hippocampus. Experiments were repeated in n = 3 rats with ...
The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop...
in rat hippocampus during global ischemia and reperfusion (IR). During IR, perfusate containing salicylic acid was collected and analyzed for non-enzymatic hydroxylation of salicylate to 2,3-DHBA. Since 21-aminosteroids can attenuate excitatory amino acid-mediated OH. production in the brain, we ...
brain subregions53. We have recently used the spatial transcriptomic approach to demonstrate neuronal activation patterns within brain regions using a deep-learning computational tool54. In this work, we have applied this state-of-the-art approach to examine activity-driven spatial transcriptomic ...
21 In the present study we have investigated whether different brain-derived neurotrophic factor messenger RNAs are specifically regulated in the hippocmapus. We provide evidence for a differential and dose-dependent regulation of the different brain-derived neurotrophic factor promoters in the hippocampus...