The hippocampus is the "flash drive" of the human brain and is often associated with memory consolidation and decision-making, but it is far more complex in structure and function than a flash drive. The hippocampus is a convex elevation of gray matter tissue within the parahippocampal gyrus in...
Brain diagram. Credit: dwp.gov.uk (Medical Xpress)—A new US study into brain function has found links between preferences and the regions of the brain involved in connecting new memories to old ones. The associations formed provide shortcuts the subconscious can use for decision making. The ...
Fig. 2.The major inputs are functionally diverse and are important for different aspects of motivational behavior.Partial connectivity diagram of major LS inputs. Arrows show if connection is input only or bidirectional. Arrow color signifies category of information that the structure provides the LS...
The hippocampus is a critical component of the brain and is associated with many neurological disorders. It can be further subdivided into several subfields, and accurate segmentation of these subfields is of great significance for diagnosis and research. However, the structures of hippocampal subfields...
Humans and other animals effortlessly generalize prior knowledge to solve novel problems, by abstracting common structure and mapping it onto new sensorimotor specifics. To investigate how the brain achieves this, in this study, we trained mice on a seri
block diagram. Right: more detailed representation of some of the principal excitatory neurons in the pathways. D, deep pyramidal cells; DG, dentate granule cells; F, forward inputs to areas of the association cortex from preceding cortical areas in the hierarchy; mf, mossy fibers; PHG, parahi...
Mild cognitive impairment (MCI) has been thought of as the transitional stage between normal ageing and Alzheimer’s disease, involving substantial changes in brain grey matter structures. As most previous studies have focused on single regions (e.g. the hippocampus) and their changes during MCI ...
Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer's disease (AD). However, the contribution of nonparenchymal or brain-infiltrated myeloid cells to disease progres
Cilia are hair-like structures composed of microtubules, which can be classified as either motile or primary based on their movement and microtubule structure1. In the mammalian brain, each of various cell types, such as stem/ progenitor cells, neurons and glial cells, expresses a single primary...
1 Generation and evaluation of Ythdf1-KO mice. a, Schematic diagram of the targeting strategy for generating Ythdf1-KO mice using CRISPR–Cas9. Two sgRNAs (red) were designed to target the fourth exon (E4) of Ythdf1. PAM sequence, underlined, green; F1 and R1, genotyping primers. b...