Thus, there is still a lack of effective target drugs for the Hippo/YAP axis in human cancer. Based on this, we shifted our strategy to inhibiting the upstream membrane receptors of the Hippo/YAP axis in gastric cancer. In the current study, we identified a novel G-coupled protein ...
Hunting by early human populations has caused extinction of three hippo species and caused great reductions in the distribution and abundance of H. amphibius. Hippopotamus amphibius inhabits the lower reaches of rivers and spends the day in water emerging at night to feed on short grass swards. ...
Discussion The Hippo signaling pathway is a known regulator of stemness, organ size control and cellular migration in sev- eral models, and thus it is of critical importance to the fields of regenerative medicine and oncology2,3. We have confirmed in the human neural system that YAP activity ...
Gansu, China. Based on morphological comparison, the species ofHippotheriumin China,Hippotherium weihoenseandHippotherium chiai, should be ascribed to the same species,H.weihoense. We also reviewe other Old World hipparion species in the very early Late Miocene and figure...
This question applies to species ranging from the simplest Amphimedon queenslandica and Trichoplax adhaerens, which lack both organs and internal structures [3, 4], to human being. The control of growth and patterning is conducted by a small set of evolutionarily conserved pathways [5], the ...
Generally, BC subtypes are classified by the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) [2]. In this context, triple-negative breast cancer (TNBC), coined under this term due to the lack of ER, PR and HER-2 ...
Next, we wanted to analyze the expression of Wts in NBs. We used an antibody against a highly conserved peptide in human LATS1-2 that we found specifically recognizes Drosophila Wts (Figure S1). Wts was detected in all embryonic NBs in a characteristic punctate pattern, and it was mainly ...
To improve accuracy and take out human error opportunities, Hippo Dx developed S.P.A.T., an automated skin prick test. This study will provide a comparison between manual and automated skin prick test in allergic and non-allergic individuals with a panel of common inhalant allergens.The primary...
The public health significance of the genus Acanthocheilonema appears to be minimal, with only one case of an adult female Acanthocheilonema reconditum reported in the eye of a human, in Australia [13]. Fleas and lice are intermediate hosts for A. reconditum [14]. Ticks, lice [15, ...
to a HFD feeding23. Meanwhile, obesity increased messenger RNA (mRNA) level of Hippo pathway effectorsYap1,Wwtr1 (Taz), and their downstream targets, such asCtgfandCyr61(Fig.1aand Supplementary Fig.1a). Transcriptome analysis of human abdominal scWAT also revealed that obesity induces the ...