[12] Zeng R, Dong J. The Hippo Signaling Pathway in Drug Resistance in Cancer. Cancers (Basel). 2021 Jan 16;13(2):318. [13] Kuser-Abali G, Alptekin A, Lewis M, Garraway IP, Cinar B. YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant ...
The Hippo Signaling Pathway in Drug Resistance in Cancer. Cancers (Basel). 2021 Jan 16;13(2):318.[13] Kuser-Abali G, Alptekin A, Lewis M, Garraway IP, Cinar B. YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer. ...
参考文献 1.Zheng, Y. and D. Pan, The Hippo Signaling Pathway in Development and Disease. Dev Cell, 2019. 50(3): p. 264-282. 2.Sanchez-Vega, F., et al., Oncogenic Signaling Pathways in The Cancer Genome Atlas. ...
摘要 如何抑制肿瘤细胞的增殖和干性基因的表达已经成为近年来科学家在癌症治疗领域关注的重点之一。肿瘤干细胞(cancer stem cell,CSC)是肿瘤中一类具有自我更新能力的细胞类群,被认为是肿瘤发生过程中的驱动因素之一。Hippo信号通路在生物进化过程中高度保守,且对细胞增殖、...
Guan, The Hippopathway in organ size control, tissue regeneration and stem cell self-renewal.Nat Cell Biol, 2011. 13(8): p.877-83. 5.Mo,J.S., H.W. Park, and K.L. Guan, The Hipposignaling pathway in stem cell biology and cancer. EMBO Rep, 2014. 15(6): p. 642-56....
When the Hippo signaling pathway is active, MST1/2protein kinasesare phosphorylated . MST1/2 ...
[2] Zheng Y, Pan D. The Hippo Signaling Pathway in Development and Disease. Dev Cell. 2019;50(3):264-282. doi:10.1016/j.devcel.2019.06.003 [3] Wu Y, Li M, Lin J, Hu C. Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer. Oncol Lett. 2021;...
Tang J, Yang Q, Mao C, Xiao D, Liu S, Xiao L, Zhou L, Wu G, Tao Y. The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway. Cell Death Differ. 2023 Feb 22. doi: 10.1038/s41418-023-01134-z....
The Hippo signaling pathway israpidly gaining recognition as an important player in organ sizecontrol and tumorigenesis, and many leading scientists are showingincreased interest in this growing field and its relation to cancer.For instance, for the past two years, over 60 researchers from all over...
1. 🔥Cell:Hippo 信号通路 (Hippo signaling pathway) 是率先在模式动物果蝇里通过遗传筛选而鉴定出来的一条发育信号通路,其在组织生长调控、组织稳态维持以及再生修复等过程中均扮演重要角色。 本研究发现, Hippo 信号通路的上游调节剂可形成功能拮抗的缩合物,并且它们合并成的共同相提供了一种在不溶解缩合物的情况...